00:00:00 > Andrew Murray: Well, welcome to the show once again. You’re listening to Ask Your Herb Doctor KMUD, Garberville 91.1 FM. My name is Andrew Murray And for those of you who perhaps have never listened to the shows, which run every third both my wife and I, who’s not here this evening, we’re both licensed medical herbalists and we graduated in England. We have a masters degree in herbal medicine and we see and advise clients with
00:01:02 > a wide range of conditions with herbal and dietary advise as well as lifestyle change advice. Okay. So you’re listening to Ask Your Herb Doctor KMUD, Garberville 91.1 FM. And, fortunately, Dr. Peat is joining us again this month for the show’s which will be broadly encompassing allergy. As a fairly pertinent time of the year, things are just starting to flower. The clocks have gone forward. We’re on summertime. Things are flowering and soon the grasses will be flowering, although they’re just not the only source of allergy related effects. But there, obviously, are plenty of other allergies, both food and environmental. So, once again, we are very welcome to – welcome Dr. Peat on the show, who is going to share his insights into the mechanisms of allergy. And as always, you probably won't have heard some of what he’s going to say related to the explanation for allergies because it's fairly new
00:02:04 > material. In fact, some of this is very old material which just hasn't been accepted. But Dr. Peat’s brave rationale on the subject of allergies is both fascinating and insightful. So thanks so much Andrew Murray: for joining us again, Dr. Peat. Dr. Ray Peat: Yeah, hi. Andrew Murray: For those people who perhaps have never tuned into the show or never read your newsletters or maybe haven't heard of you, would you just outline your academic and professional background before we get going with the shows? Dr. Ray Peat: After I had studied humanities and linguistics for a while and taught linguistics, I decided to study biology and I spent four years, 1968 to 1972, studying for PhD at University of Oregon. And in, I think it was 1969, I attended an International Immunology Conference and seeing some of the most famous immunologists
00:03:06 > in the world, I became skeptical of the standard theories of immunity. They were really ignoring some of the papers that were given at that conference in favor of staying with the stereotype official dogma. Andrew Murray: Okay. All right, well, that’s a good introduction. I know that you’re extremely talented and you’ve done a lot of work over many decades here now of your research, looking at the reality of the science behind cause and effect. And I know that you’ve written a lot of material on your own website, giving people free access to some of the explanations that you’ve given and some of which have been borne out in mainstream science recently. So that's good news that it's gradually getting out there. For those people that are listening, just wanted also to highlight the fact that from 7:30 until the end of the show at 8 o’clock, you’re both invited and welcome to call in with any questions either related to this month's topic of
00:04:08 > allergy or other subjects if you have them. But if we can try and stick on the topic of allergy, that would probably be best. So the number, if you live in the area, is the 707 number is 923 3-911, or if fortunately you're outside of the State of California and you wanted to call in from East Coast or the Midwest, we often get people calling in from those places So that’s great to hear you all out there. And I know even people in different parts of the world have tuned in. So there is a toll-free number, which is 1-800 -KMUD-RAD, which 1-800-56 8-3723. For people listening, they can also tune into the web version of the KMUD at KMUD.org and listen to the live broadcast on the air now. So, Dr. Peat, I think just starting off with some of the kind of medical model of allergy, what I've been reading and what I've understood
00:05:10 > previously from my background is that IgE is the main mediated product as an antibody product that causes the recognition and the reactive processes that lead to inflammation. What do you see of IgE as the main cause or do you even agree with that? Dr. Ray Peat: I think one of the reasons that it gets so much attention is that it fit with hereditary idea of susceptibility to allergy and other diseases. And I think the fact or that it's as much an effect of allergy as it is a cause, for example it's known that the determination of the B cells or bone-
00:06:12 > derived like blood cells to make the IgE type of antibody is determined by the signals in the body and histamine is the immediate, probably the most effective signal in telling the B cells to start making the IgE antibody. And so if you don't have inflammation from the stressed cells producing histamine, you won't be likely to have so much IgE. And one of the things that turns on the production of more mast cells or the secretion or leakage of histamine from the mast cells is prostaglandins produced from the polyunsaturated fatty acids, especially prostaglandin E 2.
00:07:14 > And over the last 15 or 20 years, several researchers have seen that allergic women have babies that are born with higher polyunsaturated fatty acid content and that those babies are more likely to develop allergies at an early age. And the polyunsaturated fats tend to decrease the low density so-called bad cholesterol and increase the HDL high-density type of cholesterol, and the HDL is associated with allergy and the higher LDL is associated with less likelihood of allergy. Those are PUFA and HDL is supposedly good things, which have been increasingly promoted are
00:08:16 > believed by quite a few allergists now to be responsible for the great increase in allergy in Europe and America. Andrew Murray: Because they are signaling for information. Dr. Ray Peat: Yes. They increase the, among other things, the prostaglandins would increase the histamine production. Andrew Murray: Yes. Okay, so you mentioned the prostaglandins, I mean, you first started talking about the IgE antibodies, they kind of go through a signaling process. So these free fatty acids, these are very self same free fatty acids that you often talk about as being important to keep down because they are both inflammatory and destructive and they are inflammatory mechanisms? Dr. Ray Peat: Yes, besides making the prostaglandins in themselves they cause changes in cells that disrupt their functions. In fact every function of the cell can be disrupted by too much of the polyunsaturated fats.
00:09:18 > And one of the worst things they do is to interrupt oxidative metabolism and the energy deficit I think is ultimately the thing that leads to really serious allergy problems. Andrew Murray: Now when you talk about energy production, again I am automatically thinking of the mitochondrial powerhouse of the cell producing energy in thyroid and progesterone being those pro- supportive supplements, nutrients for it. That's correct way of thinking about it? Dr. Ray Peat: Yes. And babies that have very young children can oxidize fatty acids very quickly and get the energy from them, but in proportion to how unsaturated they are, they over the years slowdown the ability to oxidize anything, and sugar doesn't
00:10:20 > do that. Glucose doesn't cause the great problems with metabolism and energy Dr. Ray Peat: production. Andrew Murray: Okay. So there is a kind of cumulative effect with free fatty acid build-up in the body that leads to a decrease in energy and that energy decrease is responsible in part for the arrival on the scene of the inflammatory mediators that usually poorly, poorly started. They are triggered by things which normally people wouldn't be susceptible to or allergic to. I think this is some of the rationale for why people get unexplained, so- called allergies, and I know as we get into the energy production side of your rationale on allergies, we’ll come up with some good ways to stay off that process. Dr. Ray Peat: Yes, about 40 or 50 years ago, some people
00:11:22 > associated with Hans Selye in Canada, did research on allergy and the shock that can be produced by allergens. And in one of their studies, they created allergens from potentially deadly walnut oil allergy down to very mild allergies like pollen that would maybe cause the sniffled. And they gave that branch of allergens to animals that had the glucose infused into the bloodstream to give them a twice to three times the normal concentration of Dr. Ray Peat: glucose. Andrew Murray: Okay. Dr. Ray Peat: And even the most deadly allergen didn't do anything worse than maybe give them a sniffleds when they had high blood sugar but if they
00:12:24 > ate them a little insulin to lower their blood sugar, the mildest allergen could kill them with anaphylactic shock. Andrew Murray: Got it. Okay, so sugar is a good mediator then. It's almost a stress reducing substance that prevents that cascade from even occurring and… Dr. Ray Peat: Yes, lots of people have been able to give up their EpiPens or their epinephrine dosers just by keeping a coke on hand. If they are stung by a bee that they are allergic to or they drink some coke quickly. Andrew Murray: I find it so interesting that the industry wants to demonize all those things that have been shown time and time again to be beneficial for people, so I know – so I think I've read today on one – as I was scanning the Internet trolling for different pieces of information and going there with some of the stuff that I was going to discuss with you today, I'm sure I came across an article about sugar tax that they are now imposing in England.
00:13:26 > Dr. Ray Peat: Really? Andrew Murray: Yes. Yes, I know it’s a little bit of off the subject here, but anyway sugar is very important not just in terms of energy production but for vitalizing the cell and it’s also that same sugar, then you’re saying which is directly responsible for directly reducing the Andrew Murray: inflammation. Dr. Ray Peat: Yes. When you increase – like in these animals when you give them extra glucose, it's able to get around the polyunsaturated fatty acid interference with energy production. It can turn off the production of fatty acids and get directly to the mitochondria to produce energy. Andrew Murray: Yes. I think what most people think about sugar, they’ve probably been told by mainstream media how bad it is and what your glucose should be and hear about all the diabetes that’s ramping now as a means or a reason not to consume sugar but we all know that the cause for diabetes has nothing to do with
00:14:28 > sugar and we've gone over various radio shows talking about the high fructose corn syrup in the industry's food chain and how that along with the polyunsaturated directly responsible for the rising diabetes. So sugar itself in terms of the sugar that would be necessary, and I wonder if you know, if you remember the work or the articles about the amount of sugar you say 2 to 3 times what would be normally present as an average Andrew Murray: normal blood glucose. Dr. Ray Peat: Yes. 300 milligrams percent was the protective – completely protective level. Andrew Murray: Interesting. Okay, well, you’re listening to Ask Your Herb Doctor KMUD, Garberville 91.1 FM. From 7: 30 till the end of the show, callers are invited to call in their questions about this month’s subject of allergy. We've come to that time of year now March. The clock is going forward and everything breaking into flower, where people are probably going to start coming down with the things that they recognize is the start of spring. So
00:15:30 > there is going to be plenty of advice here to understand the mechanisms by which allergy occur and how best to deal with it from a nutrition point of view. I guess the underlying pathophysiology of allergy involves the immunoregulatory dysfunction then similar to those that has been noted in highly stressed populations and we'll get into the stress side here in a moment. So the allergies themselves are now being considered psychosomatic and they’ve worsened outcomes in the patients with a high degree of psychosocial stress. How do you see the cause effect aspect of stress modulating the allergy response? Dr. Ray Peat: I remember we were talking about learned helplessness. Andrew Murray: Yes. Dr. Ray Peat: Stress that we can't escape from, even though if it's not a very Dr. Ray Peat: deadly stress. Andrew Murray: The forced swimming test Andrew Murray: of the rats. Dr. Ray Peat: Becomes deadly and that's because you can't
00:16:32 > mobilize the anti-stress system. You get stuck in the, cholinergic or parasympathetic side of the system, which tends to weaken and slow your heartbeat and weaken other defenses but it puts you in a predisposed to become inflamed condition. And when they looked at people with various inflammatory diseases, it turns out that their social economic status is additive to any particular learned helplessness situation, so that a person with any bad condition is less likely to survive if they have a low social economic status. But if they have overcome learned helplessness,
00:17:34 > they can also overcome their social economic status. They are simply addictive so that learned helplessness plus low status, low income makes you very susceptible to rheumatoid arthritis, heart disease, dementia, and so on. Andrew Murray: I wonder how best people could overcome that by, I don't know, reading – either reading stimulating articles or being involved in, I don't know, discussion dialog about alternatives that could be helpful. I wonder that's most people that have that poor situation where they are very much economically deprived et cetera have, like you say, kind of downward spiral mental outlook on things that... Dr. Ray Peat: If it’s an enriched environment is how the – I mean, the animals overcome
00:18:36 > it and in humans anything that gets you out of the trapped sensation makes your life interesting. So just about any life-enriching experience, meeting new people, going to new places helps break out of those patterns. Andrew Murray: Okay. So from an direct descriptive term then for allergies for people that are for example allergic to pollen, I know pollen is just one of many different allergens that can trigger an allergy response but in terms of some of the best treatment or some of the best approaches to this type of allergy-mediated substance, what do you think would be probably some of the most important advice people could get for Andrew Murray: combating allergies? Dr. Ray Peat: It turns out that the same things that cure or help to escape from learned helplessness
00:19:38 > also helped to stop the or reduce the inflammatory reaction and reduce histamine production. And T3, the active form of thyroid hormone was one of the early things that discovered would cure learned helplessness and it does several things that prevent overproduction of histamine. It's been known for anti- inflammatory for a long time but one of its mechanisms is to stabilize mast cells so they don't secrete serotonin, histamine and other inflammatory things. Andrew Murray: Okay. All right, so how about – we've talked in the past about you are what you eat, and then at this point in time, we are talking about ingesting allergens. So potentially you can be triggered into inflammation by what you either purposefully or inadvertently ingest. So what perhaps is a rationale or your rationale then for the gut derived
00:20:40 > link between inhaled allergens and allergy that can be decreased by specifically treating the gut with anti-inflammatories? Dr. Ray Peat: Sometimes the inflammation in a particular area like in your nose or ears or throat or eyes, sometimes that’s really something (inaudible) you can develop the IgE antibodies solely in your nasal membranes without having as in your general bloodstream, so you can have a local reaction to pollen but I think usually people who are getting these throat, nose inflammations, it's usually started from something happening in the intestine triggering mast cells which are very numerous in the lining of the intestine triggering the production of histamine, serotonin, nitric
00:21:42 > oxide and other things systemically prostaglandins in particular, and those circulate to a cause all membranes. They can cause hiatus of lumps on the skin and other skin conditions. And so avoiding things that feed bacteria so that you don't produce so much endotoxin can help all types of allergy and inflammatory conditions. And the standard theory of allergy is they used to say that only a protein is a potential allergen but there is just perfect evidence that many things that don't contain proteins are very powerful, potentially deadly allergens. For example the alginate that dentists use for making moulds
00:22:44 > Dr. Ray Peat: of the mouth. Andrew Murray: Did you say alginate? Dr. Ray Peat: Alginate. Andrew Murray: Yes, okay. Dr. Ray Peat: Which is a cousin of carrageenan which is (inaudible). One person died of anaphylactic shock so having a mould made with alginate. Andrew Murray: So allergic Andrew Murray: were they, huh? Dr. Ray Peat: Yes, it's a polyunsaturated but lots of gums like guar and locust gum and xanthan gum and so on, these are all allergens for some people but they are used just almost indiscriminately in food today’s – a label for an ice cream substitute that contains seven different gums, one of which is an allergen Dr. Ray Peat: for some people. Andrew Murray: Do you think that this the food-based dietary involvement of allergic responses could be additive in any way where people just get worse and worse because their diet
00:23:46 > doesn't change and the in-source [ph] just continue to come on in. Dr. Ray Peat: Yes, I think this is probably the worst cause of learned helplessness in the biological sense. Your body experiences that inflammatory state which is psychological as much as Dr. Ray Peat: biological. Andrew Murray: It’s so insidious too. It's so pervasive and also insidious. It's pretty corporate machine that's being driven I think down the path of destruction for a lot of people in a lot of ways but that's why I know you advocate so many good whole, not whole food as in whole food store, but so many good whole food approaches to diet and I know that your mainstay foods of choice and preference here are things like good quality dairy products whether it’s milk or cheese or… Dr. Ray Peat: Yes, the calcium and vitamin D are
00:24:48 > two of the things that are very strongly and anti-allergic. Magnesium is the most famous because of magnesium deficiency, they found caused terrific range of inflammatory diseases in animals and they would cure skin diseases, heart disease, nerve disease, liver disease and so on just by correcting a magnesium deficiency. With vitamin D and calcium working with magnesium are very important so that some people cure their allergies just by supplementing vitamin D or vitamin K which is the other major calcium regulating vitamin Andrew Murray: Okay. Just hold that thought there for a minute because we do actually have a call on there. So let's just open up the show to callers and let's see where this first call is going? Caller, Andrew Murray: are you on there? Q: Yes, Q: hello. This is David from Missouri. Andrew Murray: Hi David.
00:25:50 > What's your question? Q: Okay. I think this is still on target but I wondered about this for quite a while. Do you think there is some kind of confusion that's been going on for a long time regarding the common cold and it actually being in the same category as an allergy? For instance, you look at what happens around Christmas or the holidays, you got people that have reduced sunlight, they are eating extremely unhealthy food and they are stressed out and all of sudden Q: everybody is getting the cold. Andrew Murray: Sounds like Andrew Murray: a perfect recipe. Q: Yes, I'm just wondering, you know, and we actually see this happen throughout the year where people are labeling something a cold or they are confused – they even seen confused as do I have an allergy or do I have an cold and the other thing I wanted to ask in relation to that which I think it covers both the subjects of the allergies and the cold is, why
00:26:52 > it is mucus always a major part of either one of those? Is that the body's intelligence trying to throw off the allergens? Is it like a vehicle being used to try to exit things? Dr. Ray Peat: Yes, mucus binds histamine and keeps it away from the cells and binds other toxins and irritants. So it's our first line of defense both against allergens and viruses in such but I think there is a great similarity between the variety of viruses that like to attack the intestine, things that we think of as a respiratory viruses I think are primarily intestinal viruses. Polio in one of its manifestations was really just
00:27:54 > gastrointestinal infection but the famous gastroenterologist Walter Alvarez about 80 years ago experimented on dogs and when he would give them a respiratory virus, he found that they would get a runny nose and inflammation in their head without any virus at all present in their nose and he found that the virus was growing in their intestine and producing symptoms in their upper respiratory system. And then later if they didn't throw it off, later the virus would show up all through their system including their nose. So what seems to be a nose cold, I think most often is irritation in intestine. And I've seen dozens of people
00:28:56 > who learned that at the first sign of a cold coming on such as a sore throat or runny nose, if they ate a carrot, they could break the pattern and not develop the cold. Q: Is the common cold considered to be a virus or a germ? Andrew Murray: Supposed to be a virus, right? Dr. Ray Peat: Yes. Q: Yes. And this is interesting too especially after learning everything I have from you Dr. Peat that doctors are prescribing antibiotics even though for a long time I was always irritated with family members going ahead and going to the doctor when they had a bad cold and getting antibiotics and I would say, hey, it's the virus. So why are you doing that? Why is the doctor doing that, and they always said that it was secondary infection but in reality based on what we’ve been learning from you, it actually maybe a good thing to do because it's attacking that endotoxin issue in the intestine. Is that
00:29:58 > Q: correct? Dr. Ray Peat: Yes, I think so, and you usually don't need nearly the dose that is typically prescribed to put out a bowel infection if it has just come on. Sometimes a third of the standard dose of penicillin or tetracycline or erythromycin. Q: And then the antihistamine, so that are stifling the mucus flow in a way or really kind of disrupting the intelligence of the body getting these allergens out. Is that correct? Dr. Ray Peat: Except sometimes they can break the pattern like vitamin E has antihistamine effect. For example, it prevents the formation of prostaglandins, and as a consequence will prevent the degranulation of mast cells, and so it can prevent the shift
00:31:00 > to the IgE antibody and the whole thing. Q: You’re saying the histamine is creating a vicious cycle so we do want to break that cycle? Dr. Ray Peat: Yes, breaking the cycle. Even various antihistamines and other drugs can help to break that cycle. Q: And you said before that like nitric acid is also kind of a vicious loop going between histamine and nitric acid which you kind of created Andrew Murray: I think you mean nitric oxide I mean? Dr. Ray Peat: Yes, histamine turns on the production of nitric oxide and nitric oxide signals a bunch of other inflammatory processes, but the worst thing is that it interferes with oxygen energy production. Q: Okay. So the mucus falling though is probably a good thing
00:32:02 > but it may be a part of that vicious cycle, I guess, that we would like to stop? Dr. Ray Peat: Yes, the mucus itself is fine. It's helpful but you wouldn't have to produce it if you would then have the inflammation. Q: Okay, there you go. That's what I was looking for. Okay. Okay, well, hey, Q: thank you. Andrew Murray: Yes, thank you for your call. Okay, well, we do have two more callers and I just want to let other people listening know from now until the end of show 8 o'clock you're invited to call in with questions related or unrelated to this month's topic of allergy. Local area is 707 -923-3911 or there is an 800 number for people living in a different state across the states or outside of this area toll number, the 707 number. It’s 800-568- 3723. So we have two more callers. Let's take this next caller. Caller, where are you from? What’s your question? Q: Hi, I’m Christina from the San Francisco Q: Bay Area. Andrew Murray: Hey Christina, What's your question? Q: Before I ask my question I first just want to thank Dr. Peat.
00:33:04 > Dr. Peat you've absolutely changed my life through Dr. Murray who I’ve been consulting with over the past year. My hair has gotten thicker. My energy is increasing. Inviting depressions have tremendously improved and so I just want to thank you both Dr. Peat and Dr. Murray for all that you do. Andrew Murray: Awesome. Q: So two quick questions I have is, I've been experiencing terrible allergies for the past month and noticed that my symptoms dramatically flare up when I go to sleep like it’s very difficult for me to fall asleep. And do you know why that happens? That's the first question. The second question is what do you recommend I do to alleviate those Q: symptoms? Andrew Murray: Yes. Dr. Ray Peat: Yes, I think it's because that's when the parasympathetic system kicks in and it lowers your blood sugar and that combination turns on the histamine release and inflammation. And I experimented – I had that pattern of
00:34:06 > sleep onset asthma and I found that Jimson weed or atropine, the belladonna type chemical breaks the muscarinic part of the parasympathetic reaction. And I found that that would keep me from going in that very low blood sugar state. But the trouble is relying on the anti-cholinergic is that it tends to dry your mouth and that gives you tooth decade from the absence of saliva flow during the night. So it is an emergency treatment but the real thing I think is to adjust your thyroid and progesterone. Progesterone has broad variety of antihistamine effects. Estrogen
00:35:08 > turns on both the multiplication of mast cells and their tendency to release histamine and serotonin. And so getting your thyroid to a good level will reduce your estrogen and increase your progesterone and shift the balance in histamine production. Aspirin is another antihistamine that works indirectly by reducing prostaglandin production and nitric oxide production and such. Andrew Murray: You could easily take the three – say 325 milligram tablets in the day. I know some people who take considerably more than that and in conjunction with vitamin K one drop per 325 milligram tablet if it is one ml per drop vitamin K 2 solution is adequate to offset any potential hemorrhagic or
00:36:10 > hemodynamic effects of blood thinning that some individual may get, it’s relatively rare but so 900 milligrams a day, that would be a fairly – for people that are suffering with allergies that would also be quite a good approach to self treatment. Dr. Ray Peat: I think so. And sometimes just taking 300 to 500 milligrams before bedtime so they get time to get absorbed before you actually falling asleep. Andrew Murray: Sorry, there was another part of your question I think caller that you... Q: Those are actually – those are both of Q: I do have another one but I can let the next Q: person have a chance. Andrew Murray: Well, what's your next question? Now is the opportunity. Q: My old naturopathic doctor told me that I was getting eczema flare ups as a result of eating eggs, and surprisingly although I know that you mentioned Dr. Peat on this show many times that eggs are good for you, surprisingly eczema still comes back when I eat eggs and I get kind of a
00:37:12 > migraine after I eat eggs is the headache that really hurts. So what do you Q: think causes that? Dr. Ray Peat: Yes, I have reaction many times to – liver is the other good food that can close that reaction but when you are tending to have the high histamine or parasympathetic dominance, a dose of very high quality protein powerfully stimulates insulin production and drops your blood sugar. And so it's the same reaction that happens when you go to sleep, your parasympathetic system lets out inflammation develop. And so I learned to never eat more than about one egg per glass of 10 ounce glass of sweet orange juice at least that much to balance the protein in one egg. Q: Well, that makes sense because I've been eating two eggs
00:38:14 > and just a little bit of orange juice. So I’ll try that. Thank Q: you so much. Andrew Murray: Okay, you’re welcome. All right, so let's take the next caller. Caller you’re on there. Where are you from? Q: Hi there. This is Colman. I’m from Garberville. Andrew Murray: Hey Colman. Go ahead. What’s your question? Q: Thank you very much for this wonderful program and thank you for the graciousness of the lady that just spoke being ready to get off the phone and the guy from MO might listen. I'm interested because we're talking about anaphylactic shock and how sugar could help. And I used to carry Sudafed in my truck glove compartment because I was paranoid about rattlesnakes and I understood that that was a possible use on the way to getting help. Is sugar also something that could help in that regard? Thank you very much. Andrew Murray: Yes, I would think that Dr. Peat what's your take on that? Dr. Ray Peat: Yes, having a Coca-Cola or Pepsi I think would work but mostly people I know have had Coca-Cola work that 12-ounce glass contains
00:39:18 > but it's... Andrew Murray: It's probably 8 teaspoons Andrew Murray: or more. Dr. Ray Peat: 80% Dr. Ray Peat: glucose sugar. Andrew Murray: Okay. Dr. Ray Peat: And I think it's mostly the sugar but the caffeine contributes to the same thing helping to keep your blood sugar up and Ephedra is more powerful than caffeine but working in the same direction. Andrew Murray: Okay. When talking about Ephedra Dr. Peat, thanks for that caller, it used to be powered excellence herb for asthma. They used to use a lot of Ephedra and unfortunately got abused and withdrawn from the marketplace probably 10 years ago now. But as a stimulant and for reducing the effects of inflammation and allergies do you think that it was sympathetic drive or
00:40:20 > some antihistamine quality that it had that was responsible Andrew Murray: for it? Dr. Ray Peat: I think they are all the same thing. The pharmacologists like to talk about specific receptors being activated and so on, but there is just an extreme overlap. That's the same way that the steroid hormones, all of them overlap either positively or negatively. The Benzedrine, amphetamine, Ephedra, dopamine, adrenaline, diphenhydramine, cyproheptadine, all of these things that are – they have different names and categories but they all have a good antihistamine pro- blood sugar, pro- respiratory effect. Andrew Murray: Okay, just to share
00:41:22 > they've been in the line because of some of their tachycardia hypertensive effects I think in the extreme. I think that's probably one of the main reasons that Ephedra was pulled from the market I think people doing long-distance truck driving et cetera were abusing it to say awake and I think there were some incidences of, I don't know, probably stroke in some people or high blood pressure in others that caused them to pull off the market. Do you know if there is any of those sympathetic stimulants that maybe don't have such a stimulant effect to change blood pressure or pulse rate but would still have a antihistamine effect or one that had a different mechanism of activity? Dr. Ray Peat: Currently (inaudible) alternative that's legal is one that’s produced in the brain but it’s a close relative off dopamine and adrenaline. It's called, phenethylamine, PEA.
00:42:24 > Andrew Murray: Okay. Phenethylamine. Dr. Ray Peat: But people again are talking about 500 to a 1,000 or 1,500 milligram doses which I think are crazy. I think a helpful dose would be maybe five or 10 milligrams. Andrew Murray: Okay. And that – so it doesn't have a stimulant effect on cardiovascular? Dr. Ray Peat: Well I think it would if those end in Dr. Ray Peat: crazy doses. Andrew Murray: 500 milligrams is probably where the – okay, well you’re listening to Ask Your Herb Doctor KMUD, Garberville 91.1 FM. From now till the end of the show 8 o'clock you're invited to call in with questions either related to allergy or allergy related subjects or unrelated. The number is, if you live in the area is, 707- 923-3911, or there is an 800 number which is 1-800-568- 3723. You can use to call in between now and about 5:00 to 8:00. But Dr. Peat I wanted to quickly get onto the other subject related to allergies is the topic of
00:43:26 > atopic dermatitis. I know I've known several people with chronic dermatitis that's basically gone on to become severe eczema, weeping. And I read the article wherein – and this is one of those pub made articles that they've found 95% of people that have atopic dermatitis, chronic atopic dermatitis get colonized with staph aureus and that staphylococcal aureus bacteria that produces the yellow pus and becomes responsible for the kind of boil type appearance of the broken skin of the dermatitis that that is actually being used, the anti-stress method that we've mentioned earlier on is the cause for allergy reducing stress but not only that but you peaked my interest when you were talking about vitamin D, and vitamin D is being responsible for anti-allergy. And then again with
00:44:28 > magnesium and magnesium deficiency and how thyroid basically stabilizes magnesium in the body. Do you think atopic dermatitis is something that can be treated through the gut in the same way that you think Andrew Murray: allergies can? Dr. Ray Peat: I mean, yes, the gut and the skin have some androgens and the enzymes that are so closely connected that when one of those inflamed the other one gets inflamed. And thyroid and vitamin D are the most common solutions to those hypersensitivity of gut and skin. Andrew Murray: Okay. So we talked about environmental enrichment now as a way of changing the tide as it were against inflammation. I think we'll pick that up just after this next caller. So let's just take this next caller. You’re on the air. Where are you from? Q: Dr. Peat? Andrew Murray: Hey caller, you’re on the air. Q: I am so very grateful. Thank
00:45:30 > you very much. Q: Colorado calling. Andrew Murray: Colorado. Q: My name is Janna. The question is I wake up every night with the hypnic headache. Is it related to the caller before that it's a headache that comes on every night at 3 o'clock or 4 o'clock 1 o'clock in the morning and coffee is about the only thing that will relieve it? Dr. Ray Peat: Yes, I think it is exactly the same thing that the parasympathetic system is overactive, pushes the blood sugar down and then the inflammatory things get loose in the intestine and blood vessels. And I've used sugar and milk as a very compact and easy way to interrupt
00:46:32 > the night if you expect that to happen 1:00 or 2:00, if you wake up let's say at 12: 30 and have maybe a half a glass of milk with eating table spoon of sugar in it, that will usually help you get through the rest Dr. Ray Peat: of the night without. Andrew Murray: How would you see low thyroid as a mechanism by which to help control blood sugar and in relation to hypnic issues? Dr. Ray Peat: Yes, I think the low thyroid function is the basic thing that it develops because of accumulating PUFA polyunsaturated fats in the system and then when your thyroid is low, the prostaglandins are let loose and activate the histamine release. And so the base of the problem if you can't get rid of the polyunsaturated
00:47:34 > fats which takes years of being careful with your food, increasing your thyroid can achieve pretty much the same thing, stabilizing your tissues so that they don't release so much unsaturated fat during the night. Q: Thank you Dr. Peat. Another question, does the coffee enema, is it the same effect as drinking coffee? Dr. Ray Peat: I think drinking coffee with cream in it is better because you absorb it slowly and steadily and especially if it’s with some food maybe a raw carrot for example will extend the absorption of the caffeine and keep your blood sugar up. Q: Thank you so much. Dr. Ray Peat: Well, the coffee enema gives you a very sharp increase that can be stressful. Q: That makes sense. Thank you very much.
00:48:36 > That makes a lot of sense. Andrew Murray: Okay, thank you for you call caller. Okay, well we’ve just got about 6 to 8 minutes left, so if anybody else wants to call in either related or unrelated to this month’s subject of allergy, please do so. There is a 923 number which is 3911 for those who are local and the 707 area code, or there is an 800 toll free number which is 1-800- 568-3 723. Once again we are very pleased to have Dr. Ray Peat’s wisdom shared with us. Dr. Peat talking about some of the herb plants that have been used traditionally to treat allergies, I wonder how many of these might actually have more of a gut-related anti -inflammatory effect and that is how they become allergy treatable type approaches. So things like turmeric. I was reading – I mean we know all about turmeric in terms of its anti-inflammatory anticancer type mechanisms but I wonder whether those (inaudible)
00:49:38 > and those other potent compounds within turmeric, could be more gut-related in terms of their anti-inflammatory effect in that way have an effect on allergies. Dr. Ray Peat: I suspect they are. The soothing – the famous soothing teas such as chamomile I think are working largely on the intestine and (inaudible) definitely acting on the intestine primarily. Andrew Murray: Have you heard of a compound called cromolyn and sodium cromoglicate. Dr. Ray Peat: Yes, I've never used them but I've heard them Dr. Ray Peat: a lot. Andrew Murray: These actually – look, and they come from a plant – an Egyptian plant that I’ve known in herbal medicine but I've never used it called Ammi visnaga. Apparently it is being used for a couple of millennia in Egypt. So that's one of those other alternatives. And then the methylxanthines, I know I've heard you speak fairly extensively about
00:50:40 > xanthines and methylxanthines before, so things like theophylline from cocoa beans and apparently contain and a lot of methylxanthine. Dr. Ray Peat: Caffeine is my favorite of the category but there is one that's used medically that has, I think it's five carbon added to it to make it a little more stable in the intracellular. It's a yellow, I can't think of the name of it but it's medically approved version of caffeine. Andrew Murray: Okay. All right, I'm not sure – are you aware of – I know you mentioned Datura quite a lot too as being a good anti- cholinergic and its muscarinic antagonist then but – and I know we’ve talked about that dry mouth syndrome for me in herbal medicine
00:51:42 > traditionally in England I can't say that I do it here because I'm not allowed but in England I could prescribe Datura or I try for belladonna and give it to the patient with a caveat that when they just began to get a dry mouth that would be their threshold point at which they could back of their dose slightly and that would be their maintenance dose for treating them for asthma, for example with Datura. Do you know whether or not the physiological tolerance for something like that class of compounds to be used for allergies and asthma could be tolerated over long- term? Dr. Ray Peat: Yes, I think that dry mouth is really the only serious side-effect. I've known people who loved it so much that they ruined their teeth. Andrew Murray: Because they used it enough because that was what they were using it for you’re saying because it was… Dr. Ray Peat: Yes, they would have night seizures or night asthma or night headaches
00:52:44 > or whatever. It's very good for that but it's very bad to (inaudible). You can do the same thing safely with the oily vitamins, vitamin E, vitamin D, vitamin K in particular and vitamin B6 are important for stabilizing the mast cells and blood sugar, and magnesium is essential, it works with thyroid. So you can't expect magnesium or thyroid to work perfectly without the cooperation of the two at Dr. Ray Peat: the same time. Andrew Murray: Okay, so once again then we come back to the subject of adequate sugars, adequate thyroid hormone, avoidance of the polyunsaturated blocked thyroid hormone and the necessity of getting clean diet with bowels moving correctly
00:53:46 > and not suffering from constipation and reabsorbing endotoxin as a pretty good way forward in terms of just those things which are fairly easy to do for the approach to asthma and/or allergies in general. And I think getting back to the gut origin of allergies that you made that link not just to the kind of inspired respiratory airborne allergens but actually a lot of it can start in the gut and I know you mentioned a lot in the past cascara as a good bowel laxative and a compound with which has a fairly similar structure to tetracycline Andrew Murray: chemically. Dr. Ray Peat: Yes. And the drug companies are seeming get interested in it as a cancer treatment for dementia and heart disease and it has a tremendous range of beneficial protective effects besides Dr. Ray Peat: protecting the intestine. Andrew Murray: So I'll have
00:54:48 > to watch out for that one being banned I presume. Dr. Ray Peat: Yes, it's so good. Andrew Murray: In the short term it will just get too many good things going for and I'll probably of the market under the guidance of some toxicity I would think. Anyway. all right, well it's 5:28 and obviously too late for anybody else to call in. But wanted to just thank you so much for your time and giving of yourself to come to these radio shows and I know that you’ve become pretty much the mainstay of the show here for quite a few years now, so I do appreciate your time and appreciate everything that you do for us Dr. Peat. Dr. Ray Peat: Okay. Thank you. Andrew Murray: Okay. So for those people that have listened to the show and want to know more about Dr. Ray Peat and about his work and his life, his website is www.raypeat .com, R-A-Y-P- E-A-T dot com. He has lot of articles there which are fully referenced, bibliographic fully referenced articles, very scientific. I know some of it’s a little heavy going if you are just
00:55:50 > an average person who doesn't really have a science background but there is enough in the writing there anyway just to get the gist of what he is saying and some of the stuff also could be looked up. But anyway it's very well worthwhile reading a lot of the material you won't find it anywhere else. A lot of what he advocates you will not hear the mainstream media advocating. So www.raypeat.com. We can be contacted anytime Monday through Friday on 1888- WBM-HERB or our website address is www. westernbotanicalmedicine.com. So we are in the spring time now and it will be just be getting lighter and warmer and brighter and dryer, so those have to look forward too but for those people perhaps who are going to get the allergies coming on here, I hope there has been lots of information in this show not both dietary but for those other things that one can do to either avoid the learned helplessness in social environments and also to enrich their environment with
positive things as well as using herbs and other supplements to which to offset that inflammation that is the hallmark of allergies. So until the third Friday of next month, thank you so much for joining and for those questions who called in, thank you for your time. Talk to you next third Friday of April. Good night.