Herb Doctors: Longevity And Nootropics

PODCAST | Ray Peat

null | Ray Peat

00:00:00 > ANDREW MURRAY: Well, welcome to this

00:02:18 > evening’s Ask Your Herb Doctor. My name is Andrew Murray. SARAH JOHANNESEN MURRAY: My name is Sarah Johannesen Murray. ANDREW MURRAY: Excuse me for not having the audio track. Okay, anyway. So thanks very much for joining us. As always, Dr. Peat is joining us on the show. Tonight’s subject is going to be a subject surrounding longevity and brain foods. Dr. Peat’s latest newsletter is on cognition. It’s a continuing theme of his and we want to bring out some of the new thoughts surrounding that. The number if you live in the area – it’s a call-in show from 7:30 to 8 PM. The number, if you live in the area, is 923 -3911. Or if you’re outside the area, there is an 800 number, which is 1-800-KMUD -RAD. Incidentally, it is also the pledge drive for the radio station. And just those people who are listening to the show, just want to reemphasize, from my own personal perspective,that it’s a very unique radio show, which allows a very diverse

00:03:20 > range of topics, and those topics are not always – not usually even things that you are going to hear in the mainstream. So it is a very important radio show to support… SARAH JOHANNESSEN MURRAY: The station. ANDREW MURRAY: Radio programming. SARAH JOHANNESSEN MURRAY: Radio station. ANDREW MURRAY: Radio station to support. Yeah, very much appreciate any pledges that people would like to make or sponsorship donations, etc. So we will be having a few brief interludes during the show and be talking about that. Okay. So I think without any further delay, let’s see if Dr. Peat is on the air. You there with us, Dr. Peat? RAY PEAT: Yes. I’m with you. ANDREW MURRAY: Hi. Just so that people who perhaps have never listened to the show or have never heard you, would you just given an outline of your academic and professional background before we get into tonight’s subject? RAY PEAT: I studied humanities first, largely at University of Oregon and a year at Ohio State, some in Mexico and so on. But then I went to the University of Oregon for four years to study biology.

00:04:22 > And I’ve been concentrating on biology now for 40 years or more. ANDREW MURRAY: And I know that you are intimately involved in – for want of a better phrase – uncovering the truth behind various claims and, yeah, propaganda almost, from everything, I would think, some of the pharmaceutical and other corporations with how they would market their product to us as consumers and how that marketing is really not very scientific a lot of the times and there is scientific evidence to show an argument to support most, if not all, of what you write about in your newsletters. And just reminding people that listen to the show, Dr. Peat doesn’t sell anything. He is very much into research. And a lot of what you do, I know, from our own experience and from people that have contacted you is very altruistic. So tonight’s show, like I said

00:05:24 > at the beginning, here is going to be surrounding longevity and the popular sort of – popularly recently exploded promulgation, if you like, of brain foods supplements etc. Nootrophics, I think, they’re commonly referred to now in the buzz circles. But looking at longevity first, we did a show, a few months back, and it was entitled You are What You Eat and I know we expanded on things that you consume can definitely affect your emotion and your psychology. With respect to longevity written in your recent newsletter that the intestinal tract of parrots and ravens contained only a few species of bacteria and is positively correlated with longevity in these species, the intestines being a major source of toxin. And I was quiet shocked when I saw it because I know that ravens are carrion birds and you would think that dead and dying tissue and rotting flesh would be a pretty good source of

00:06:26 > a wide range of bacteria. So in terms of bacterial toxins in the gut and the bacteria, what have you found about the intestinal population of bacteria? RAY PEAT: Well, birds have a very high body temperature, and so, probably, have extremely fast digestion and ability to extract everything good from the food, taking it away from potential bacteria. So it’s just so fast that the bacteria don’t have much of a chance at multiplying. And incidentally, besides being very long lived, those birds are extremely intelligent, can solve extremely complex problems very quickly. There is a lot of stuff on the Internet, videos about birds solving problems. So I think the cognition and

00:07:28 > longevity go closely together. When you cause animals to live, to grow up their whole life free of bacteria, they have some advantage in stress resistance and have a somewhat increased average lifespan, a high metabolic rate. A lot of the stuff produced by the bacteria ends up simply slowing metabolism and the aging process itself, right from earliest life, is a process of slowing the metabolic rate. So things that retard that slowing should extend lifespan as well as a good cognition. ANDREW MURRAY: That actually reminds me of another phrase, the

00:08:30 > wear and tear, and the relationship between activity and running at a high metabolic rate and running out of energy and/or wearing out being kind of the opposite of what we are saying here about highly increased metabolic rates being actually productively beneficial for the organism in terms of clearing waste material and/or processing reactions that would denature toxins or clear waste, etc. RAY PEAT: When I was in grade school and high school, it was common that if you were very active, had a high metabolic rate that you would die young. And that always annoyed me that people had the image of a candle, the brighter it burns,the shorter its life expectancy. SARAH JOHANNESEN MURRAY: Is this why a baby starts out with such a

00:09:32 > high pulse rate and is so warm and has a high metabolism and then it’s just aging that changes that? RAY PEAT: Yeah. Puberty especially. It gradually slows down. When a calf is born, for example, it’s – all through its body, including its brain, are highly saturated because the mother has been saturating the fats from the food, and so it’s protected from the environment. And as its tissues absorb the polyunsaturated fats, its metabolism slows down. And you can see it in ruminants because they start life extremely free of polyunsaturates. But human babies are, according to some fat experts, everyone is born deficient in the essential fatty acids, and so they advocate putting

00:10:34 > more of them in baby formula. But actually those are major things in slowing metabolic rate and they tend to accumulate in the brain with aging, slowing metabolism, especially the ability to metabolize glucose all the way to carbon dioxide. So the old or demented brain x has a chronically high level of lactic acid because it has progressively lost the ability to oxidize glucose to carbon dioxide. SARAH JOHANNESEN MURRAY: And a lot of polyunsaturated fats. I just find it strange that the placenta filters out the polyunsaturated fats. RAY PEAT: Yeah. That’s why babies are born with a so-called fatty acid deficiency, but that’s a natural thing that the baby makes its brain fats out of the glucose or fructose that it’s getting from the mother. SARAH JOHANNESEN MURRAY: I know it’s justso strange that they say the baby has a deficiency, when maybe that’s how it’s supposed to be, if that’s the way it is.If the

00:11:36 > placenta filters it out, maybe the baby is not supposed to have them. So don’t start giving your baby fish oil as soon as it’s born. RAY PEAT: Yeah. There have done experiments with rats and dogs and other animals in which the mother is given a high unsaturated fat diet or a PUFA-free diet and the babies have a bigger brain and better problem- solving ability when their mother was free of PUFA during gestation. ANDREW MURRAY: Okay. So the first thing then, the intestine is being clean because of being a major source of toxins, definitely accumulates inflammatory, degradative processes and contributes to a shorter lifespan. How about the manipulation of hormones then?And I know there was an experiment that I’d like you to bring out. I know we can’t do it to human beings perhaps or people of the street. But

00:12:38 > a fellow called W.D. Denckla did an experiment removing the pituitary gland. And this was shown decisively to increase life and/or reduce the rate of aging and the hormones that are born by both the anterior and posterior pituitary – things that I know you’ve mentioned lots of in the past, things like LH, FSH, TSH, and oxytocin – are also very responsible for a lot of the inflammatory processes. RAY PEAT: He found that, in general, the pituitary extract, if you injected it into an animal,slowed the ability to oxidize glucose. And so, he called the death hormone the oxygen- blocking hormone. And he tried to extract

00:13:40 > a specific protein. It was closely related to prolactin or growth hormone, but he never did identify a single protein, probably because several pituitary hormones do have some oxygen-blocking function. Growth hormone is really an adequate model for what Denckla was looking for. He thought it was closer to prolactin, but that whole range of either prolactin or growth hormone can interfere with oxygen metabolism and it’s now widely recognized that the more growth hormone you have, the shorter your life expectancy. SARAH JOHANNESEN MURRAY: Anything doctors give patients growth hormone. RAY PEAT: Yeah. The famous Methuselah Mouse is

00:14:42 > deficient, lacks the ability to produce growth hormone. And when a genetically- modified mice, so that they produce more than the normal amount, they’re very short-lived. So just anything you can do – you don’t have to do surgery on the pituitary. You can live in a way that reduces the activity of those hormones. For example, when you get hypoglycemia and any stress tends to sharply decrease your blood sugar until you adapt, but simply an episode of hypoglycemia increases your growth hormone and that activates the whole process of changing your type of metabolism, blocking oxygen production relatively, the ability to oxidize glucose to carbon

00:15:44 > dioxide, and it tends to increase phosphate, which is one of the things that happens under the influence of bowel toxins. ANDREW MURRAY: And it’s the ratio of phosphates to calcium that you’ve always mentioned as being important to get dietarily, so that you get enough calcium in relation to phosphate because the phosphate from meats, particularly muscle meats etc. and nuts and things, can be fairly damaging. RAY PEAT: Yeah. It’s now considered one of the most important toxins of kidney disease or uremic toxins. Simply a natural phosphate that everyone has circulating, but when it increases because of the hormonal metabolic problems, that is a typical strong sign of the aging process. And the aging or anti-aging hormone or protein called klotho is a

00:16:46 > very powerful regulator of the balance and handling of a phosphate. ANDREW MURRAY: Okay. Let’s hold you there for a moment, Dr. Peat, because we’ve got a couple of people in the studio here who’ve got something to share with us. So let’s just take this next five, whatever the minutes and get through this. CARRIE: Sure, yes. This is Carrie and I'm here with… Moren: Lauren, otherwise known as El-dog. CARRIE: Alright. Thanks, Lauren. And we’re here to thank some people. We are in our pledge drive and we know that a lot of people listen in from all over the place for this show. It is so much important health information and KMUD to support these locally- produced shows needs community support. And if you are listening right now, you are part of the community. In fact, you can become a new member of KMUD and we really love that. We’ve got 20 new members this pledge drive. We’re really excited about that. Thank you each and every one of you. And we’ve got some people to thank for their donations and we’d like you to please consider making a pledge. You can pledge right online. There is a donate button right at KMUD. org or you

00:17:48 > can call 1-800 -KMUD-RAD. That’s 1-800- 568- 3723. Or you can call locally 707-923- 3911. I’d like to thank Jeff over by Horse Mountain. He says thank you for the fire information. And, Jeff, we know you’ve got smoke and fire really close by. So hope you are safe out there and thank you so much for listening to KMUD and listening for all the fire news and thank you for your pledge. LAUREN: And we’d also like to thank Loris from Red way, who says thanks for fire reports and Tuesday is her favorite day. CARRIE: Right. Yeah, we’ve got the – people have favorite days here all the time. So thank you, Loris. And an anonymous donation, thank you so much. Wanted to do a shout-out to people to please watch out for cyclists on the road. We’ve got windy roads here and look out. And if you are a cyclist who needs bicycle

00:18:50 > repair, check out Humble Underground Bicycles, we will fix you up. LAUREN: And they’re good. I bring my bike tires in there to get repaired. CARRIE: So if you make a pledge here and give us a call, you can give a shout-out too. We love to hear whatever one has to say and their shout- outs on KMUD. So thanks very much and thanks for the show and all the important information. LAUREN: And Smokin’ Moses from Myers Flat. And I’m sure Smokin’ Moses knows to put your cigarette butts out. Don’t just throw them outside because bad stuff happens. CARRIE: Right. Thank you, Smokin’ Moses. And we have lots of thank you gifts for people. If you make a pledge tonight and El-dog has a special one just this evening. What do you have to offer listeners? LAUREN: Tonight, it’s perfect. Since it’s the Herb Doctor show, I have St. John's wort home brew available for the next person who calls in and does the sustaining membership. Love to hook them up. SARAH JOHANNESSEN MURRAY: Wonderful. CARRIE: All right. You’ve got that St. John’s wort

00:19:52 > homebrew. LAUREN: It’s delicious. ANDREW MURRAY: Can I ask you how made it? CARRIE: I made a mash and added some yeast and little bit of magic wand waving – I'm just kidding. Lots of love and… ANDREW MURRAY: Okay, cool. Okay, good. Did it change color? What color was it when you finished that? CARRIE: Bright red. ANDREW MURRAY: Alright. CARRIE: Bright red. I was wondering, but the St John’s wort really brings out their red. ANDREW MURRAY: Yeah. Excellent. That’s what you get when you infuse the flowers in a good quality, saturated oil or a jojoba particularly. Yeah, excellent. CARRIE: Great. Well, have a great rest of the show. We’ll come back with more. Thank you. ANDREW MURRAY: For sure. CARRIE:[inaudible]. We see the phone ringing, so we’ll come back with more thank yous. ANDREW MURRAY: Absolutely. That’s what it’s all about. CARRIE: Thanks so much for supporting KMUD. ANDREW MURRAY: Yeah. Thanks for keeping it all alive. Okay. So carrying on with the topic of longevity and brain foods – I think actually before I start that up, I just wanted to mention that, last month, we did a little expose of two

00:20:54 > gifted young individuals, who had an idea and they just followed it up, and did an interview with six leading alternative scientists. Dr. Peat was one of them. And they had a Kickstarter and they produced a documentary. And it was their goal to produce a full film, all about some of the misleading thoughts in medicine and how medicine and science has kind gone of the straight and narrow and become fairly deranged in its beliefs. And Brad and Stuart… SARAH JOHANNESSEN MURRAY: Brad and Jeremy. ANDREW MURRAY: Sorry, Jeremy/Stuart, Brad/Adams. Wanted to reach a goal of $35,000 for their Kickstarter to enable them to get to post production. And then, at that point, they would have a very viable and tangible film to bring to bear and will get further funding and produce it. While they smashed the $35,000 record and they got $76,000 in their

00:21:56 > Kickstarter. So well done. Okay. So, Dr. Peat, I wanted to also ask now about the anti-aging effect of the – the proposition that diluting your blood serum or your lymph can actually increase your lifespan because of removing toxins and how the kidneys themselves – when the kidneys fail, how they can damage bowel function. And I was wondering, is it possible that we could practically dialyze ourselves, like, you know, patients go for dialysis when they’re diabetes, etc. SARAH JOHANNESEN MURRAY: What about bloodletting? ANDREW MURRAY: Bloodletting? SARAH JOHANNESEN MURRAY: Don’t blood donors have an increased lifespan? ANDREW MURRAY: They have a little iron, don’t they? RAY PEAT: Yeah, at least a healthy lifespan. I am not sure about the maximum, but they are relatively free of degenerative diseases.

00:22:58 > And annual experiments have been done now forx 75 years. There’s one of the simple dilution experiments where they took out a dog’s blood, centrifuged it, threw away the liquid part, put a saline solution back into replace the red blood cells and did that repeatedly. ANDREW MURRAY: Wow. RAY PEAT: So that there were enough washings, the whole animal’s body fluids had been turned over and exchanged. A decrepit old dog of, I think, something close to 20 years became frisky and really effectively rejuvenated. ANDREW MURRAY: Wow. That’s interesting. I guess then, obviously, there’s no damage to the red blood cells from centrifuging them and/or any other solid matters not damaged by the g-forces and it can be

00:24:00 > re-suspended in a clean fluid. RAY PEAT: Yeah. ANDREW MURRAY: Interesting, wow! RAY PEAT: And the bowel toxins are always entering the blood and having it be removed by the kidneys. But they poison not only the kidneys, but the heart and the brain and the liver and the intestine in the process of being filtered out. And so, the blood contains some of these toxins, including the normal lactic acid and phosphate simply in excess as well as the specific bacterial toxins. But also as these toxins effect the various tissues and organs, the body produces defensive reactions and these defensive reactions, including pituitary hormones,

00:25:02 > become part of the toxic environment circulating in the fluid. And so, the shift away from circulating renewal signals produced by the animal becomes gradually, with age, circulating stress signals rather than renewal signals. And so, if you put the young blood into an old animal, you are causing a slight shift back towards some of the renewal signals, but you aren’t necessarily decreasing the age from stress signals. ANDREW MURRAY: And that is very much like a bystander effect as well, right? RAY PEAT: Yeah. It definitely is the same process that happens in the bystander effect when you injure a cell orx a particular region, for example, with a beam of

00:26:04 > focused ionizing radiation, x-ray meter, your foot or hand or tooth or whatever that tissue emits the signals which are the same as the aging and stress signals. And so, the radiation damage is very similar to the process of itching. And the intrinsic regulatory processes instead of being increasing your ability to adopt, they start narrowing the way you’re adapting. And it creates a vicious circle, for example, in which something interferes with your oxidation. And in reaction, that leads to lactic acid production instead of carbon dioxide. And the lactic acid is one of the toxins that turns on the production of nitric oxide, which spreads

00:27:06 > inflammatory signals and blocks the ability to use oxygen. So you get a – in that case, it’s a very quick feedback process, in which it just gets worse and worse unless something intervenes to either stop the production of lactic acid or of nitric oxide. ANDREW MURRAY: Okay, excellent. I think if you were to ask people on the streets whether nitric oxide was bad for you or good for you, I think most of them would say that it was good for you. It’s so wrong. RAY PEAT: The September issue of Life Extension magazine has an article mention on their cover, how to increase your nitric oxide and it gives a several -page article, describing their product that contains some very nice flavonoid compounds extracted from oranges or something, but the theory that they use to sell them is

00:28:08 > that they all increase your nitric oxide. And they give two references saying that, and so I looked up that subject, what hesperidin does to… ANDREW MURRAY: Hesperidin? RAY PEAT: Yeah. ANDREW MURRAY: Okay. RAY PEAT: …to nitric acid. And I found – I don’t know. I think it was probably 30 or 40 articles saying that these are anti-inflammatory because they block nitric oxide. ANDREW MURRAY: Right, right. So they got it. SARAH JOHANNESEN MURRAY: So people will feel better using them, but they are selling them as it’s increasing nitric oxide when, in fact, it’s doing the opposite. RAY PEAT: Yeah. ANDREW MURRAY: I wonderif the editor might appreciate the comment, okay. SARAH JOHANNESEN MURRAY: I know someone should write to the editor of Life Extension magazine. ANDREW MURRAY: Okay. You are listening to Ask Your Herb Doctor on KMUD Garberville 91.1 FM. And from 7:30 till the end of the show at 8 o’clock, you are invited to call in with any questions either related or unrelated to this month’s subject of longevity and brain

00:29:10 > foods. I think in the next half an hour here, we’ll get into some of we’ll get into some of the brain foods. People might have heard about them. People might have used them. I know Dr. Peat certainly knows what he is talking about. And some of the science that might support some of these brain foods, I know that he would have alternative information that I think people should be aware of. Some of them are very innocuous, some of them have a very good background, some of them have very less in scientific background. So brain foods, I think, is going to be the next thing that we’ll get into. But if people have any questions about them or about longevity or how to approach, 923-3911 or the 1-800 number is 1800- KMUD-RAD. So the subject of nootropics being the word as used to describe a product that would be improving your cognitive ability, your mental prowess, your performance, skills etc., and your alertness and readiness. There is lots and lots out there and

00:30:12 > I am not surprised that most people don’t really understand it and probably bite the hook that’s the shiniest and glossiest and fanciest hook. It looks it must work because it has got such a good advertising campaign behind it. I wanted to explore then the subject of nootropics with you, Dr. Peat, and ask whether you can support or refute the claims made by various manufacturers of performance and cognition improving substances as plausible or poor science. And I think – I wanted to start with a widely known – in the trade anyway – a compound called acetylcholine, which is a neurotransmitter responsible for improving memory, learning, problem solving ability, and general cognition. What are your thoughts on this substance? RAY PEAT: The current and the last 20 years, popular medical approach to treating Alzheimer’s disease is to

00:31:14 > try to increase the level – or production or persistence of acetylcholine by blocking the enzyme that breaks it down. And they have demonstrated basically that it doesn’t work, and so they need the new fundamentals theory. But their theory is so mistaken that it’s hard for them to get off on to a new line of drug treatment because the acetylcholine, it’s essential and part of our conscious regulating – it’s needed for memory, all kinds of biological processes require just the right amount of acetylcholine. But it activates the enzyme that produces nitric oxide. And nitric oxide blocks energy production,

00:32:16 > and so the process of excitotoxicity, which made monosodium glutamate notorious because a little too much of that activates the production of a little too much acetylcholine and that makes too much nitric oxide. Nitric oxide poisons the ability to oxidize glucose to carbon dioxide, so it increases lactic acid. And the cell has less energy and is more excited by the acetylcholine. So, basically, it becomes susceptible to dying in proportion to the over-stimulation of acetylcholine. SARAH JOHANNESEN MURRAY: And is it true that MSG can cross the blood brain barrier and cause that reaction in the brain? RAY PEAT: Oh, sure. The amino acids all have to get into the brain to provide brain proteins

00:33:18 > and such. And it’s just one of our normal amino acids. But too much of it becomes toxic or too little of the other amino acids and a relative disproportion of glutamic acid. Aspartic acid and cysteine are the other potential nerve toxins. Again, by increasing acetylcholine which increases nitric oxide blocks oxygen metabolism of glucose. ANDREW MURRAY: Oops. So another good case in point of more is not better. In your opinion, do you think most people have enough acetylcholine in their systems? RAY PEAT: Yeah. Actually, I think that tendency with aging is to have too much of the shock reaction. For over

00:34:20 > 100 years now, there has been evidence that over-activity of the vagus nerve and parasympathetic nerve system produces shock that it’s the essential factor in shock. And this is the system that acts primarily through acetylcholine producing nitric oxide. Nitric oxide blocks oxygen metabolism. So in shock, your blood stays red and full of oxygen that the tissue can use it. And that happens with aging, heart failure, kidney failure, dementia, all the tissues relatively have a shock-like metabolism that progresses with aging. ANDREW MURRAY: Do you think there’s any medical benefit or interest in increasing the breakdown of acetylcholine? RAY PEAT: Yeah.

00:35:22 > There are lots of therapeutic uses of things that block the over-activity of acetylcholine and accelerated its turnover. A rich environment increases the enzyme that breaks down acetylcholine. ANDREW MURRAY: So the environmental enrichment then would encourage the breakdown of acetylcholine? RAY PEAT: Yeah. Having a good life protects you against much. SARAH JOHANNESEN MURRAY: Protects you against lots of aging problems, right? RAY PEAT: What? SARAH JOHANNESEN MURRAY: Having a good life protects you against lots of aging problems? ANDREW MURRAY: You have to clarify the term good life. We don’t mean drinking and partying and… RAY PEAT: No. Having lots of fun, reading interesting things, talking to interesting people. ANDREW MURRAY: Yeah. And having interesting jobs, doing interesting work and liking your job, not because it pays you well, but because you are fundamentally interested in

00:36:24 > it, which is what you should always pursue in your life. RAY PEAT: Yeah. SARAH JOHANNESEN MURRAY: It might pay well too. ANDREW MURRAY: Well, that’s a benefit – that’s a positive benefit. That’s a blessing, but it’s not always… RAY PEAT: Be absent of learned helplessness. ANDREW MURRAY: Right. RAY PEAT: Or behavioral despair. ANDREW MURRAY: Okay. RAY PEAT: Most people treat their jobs with some learned helplessness. ANDREW MURRAY: How can they do anything different? They spend all this time – well, perhaps in some instances, they spend all the time studying for a particular degree or whatever education and then they get into the work and find out how odious it is and decide that – what can they do about it? I don’t know. Okay, yeah, learned helplessness, another very interesting topic. I know you’ve spent quite a bit of time talking about learned helplessness and how that plays psychologically into physiology and how it can have definite effects on the organism in terms of decreasing its survival odds. RAY PEAT: That brings up another product line that is being pushed recently, the

00:37:26 > methylating agents, because learned helplessness is a matter of imprinting, turning off the genes that should enlighten you, increase your adaptability. Too much methylation shuts things down, makes you helpless and that process happens progressively with aging. Too much methylation turns off the fields of renewal. And there are lots of products pushing the idea that we need more methylates. One of the main methyl donors is methionine, the amino acid. And if you deprived animals of a major part, I forget the exact percentage, but half or less of their normal methionine, they live 30% or 40% longer than they would otherwise.

00:38:28 > SARAH JOHANNESEN MURRAY: What’s a common food source that’s high in methionine? RAY PEAT: All of the high protein foods like meat. ANDREW MURRAY: Okay. So this is, again, another good reason to advocate the fact that muscle meat in isolation are not good for you and that balanced proteins from the whole animal, including the connective tissue and gelatin, is the best way to consume a protein. RAY PEAT: Yeah. Gelatin is unique in being free of the pro-aging aminoacids. And another bad thing about meat is its very high ratio of phosphate and calcium. SARAH JOHANNESEN MURRAY: And so, is this similar to adventuresomeness? RAY PEAT: To what? SARAH JOHANNESEN MURRAY: Adventuresomeness. It’s a phrase that my dad’s always using. He reads articles about people and cultures that have more adventuresomeness than others. ANDREW MURRAY: More More adventure. SARAH JOHANNESEN MURRAY: They’re into adventure. RAY PEAT: Yeah. That’s what

00:39:30 > an enriched environment gives you the opportunity to have the adventure everyday. ANDREW MURRAY: Good. Allows your brain to grow and to seek new opportunities and limitless potentials. That’s what life should be all about. Okay. There is a little – gosh, just a little one-liner I just wanted to mention, which kind of really supports the whole energy metabolism or the increased energy, increased metabolism being very pro-life was that – there’s a little sentence here that was part of – I think it was part of your newsletter, Dr. Peat. You said that heart rate corresponding with academic standing and the only patients improve when their pacemaker was turned up. RAY PEAT: Yeah. They noticed that people with a faster heart rate had higher academic records and they thought maybe it was just a better brain circulation. People with very slow

00:40:32 > heart rate were getting enough oxygen to the brain, so they had patients with the adjustable pacemakers, and so they gave them Mendel tests when it was set at 70 beats per minute. And then they turned up the rate to 85 beats per minute, gave them the same test, and they scored better in all types of brain function, memory, reasoning. ANDREW MURRAY: Yeah. And it is so popular in culture to believe that if you have a low pulse rate you are healthy, you are fit, you are super athletic. And like these people that have pulses of 50 beats a minute, they suddenly die of heart attacks. They’re not like – they’re not long-lived at all. And it’s a complete brainwashing that low heart rate corresponds with longevity because it’s the opposite. SARAH JOHANNESEN MURRAY: It is the bodybuilders that live a long time, not the long distance runners. ANDREW MURRAY: Well, maybe the bodybuilder might wear out their joints too, but… RAY PEAT: Or take too many chemicals. ANDREW MURRAY: Or take too many chemicals. Definitely, the big bodybuilders usually that are all over the press and news. Okay. Let’s just –

00:41:34 > I just wanted to bring out a couple of nootrophics in the herb world and just see if there is any – I know there is a connection there, but to see the connection that there is. Sage, believe it or not – I’ve always known sage to be a kind of cleansing purifier, a mouthwash, it can be used for boggy gums that are not holding the teeth properly. Definitely can be used for respiratory conditions. But sage apparently here now – there’s fairly recent articles on PubMed that it has a cholinesterase inhibiting property. Now, this is something that you mentioned earlier on with acetylcholine. So the enzyme that produces acetylcholine is acetylcholine esterase and salvia inhibits that. RAY PEAT: Every plant, like every animal, has thousands of different chemicals. And sage has –

00:42:36 > I'm not sure how it relates to other drug effects, but that is one of its component’s action is to shift the balance to increased acetylcholine action. ANDREW MURRAY: Yeah. RAY PEAT: But two of its major tripping type chemicals are inhibitors of nitric oxide, salvianolic acid, I think, one is called… ANDREW MURRAY: Okay. RAY PEAT: …and the other Chinese or Japanese name, teschianone [?] something like that. ANDREW MURRAY: Okay. RAY PEAT: These are very effective inhibitors of nitric oxide, so they’re anti-inflammatory and pro- respiratory. SARAH JOHANNESEN MURRAY: So is this why it probably has an action with reducing menopausal hot flashes asit’s reducing nitric oxide and…? RAY PEAT: Nitric oxide does cause flashing and is connected with hot flashes. So

00:43:38 > I think probably the dominant effect is due to lower nitric oxide where the cholinesterase inhibitors will tend to increase nitric oxide by stimulating the acetylcholine nerves. ANDREW MURRAY: Okay. Well, then, I guess, moving onto ginkgo. Most people know ginkgo. It has been used for a long time in the Chinese traditional medicine system, more particularly for elderly people to improve cognitive function. They say that it improves blood flow to the brain, increases cerebral blood flow, and that would seem to be in keeping with turning up an elderly patient’s pacemaker, increasing their heart rate and their cardiac output. But I think the vasodilating effects of the cerebral arteries is probably more the point with ginkgo. But also, I wanted to bring out what, again, maybe mis-commonly known as good when it’s not perhaps is the link between

00:44:40 > monoamine oxidase and then ginkgo apparently decreases monoamine oxidase and that increases dopamine. Now, I know they treat – well, unscientifically, perhaps, they might treat Alzheimer’s patients with L-Dopa and dopamine might be touted as a precursor as a product to do that. What are your thoughts on dopamine and monoamine oxidases? RAY PEAT: It definitely makes you feel good. It’s sort of an upper to do anything that increases your dopamine. It tends to increase adrenaline usually and certain types of MAO inhibitors will increase serotonin too. ANDREW MURRAY: Right, which is not good. RAY PEAT: Those don’t necessarily go with well-being. The brain circulation, for example, is decreased serotonin. It tightens up the blood vessels,

00:45:42 > especially the veins leaving the brain. So if you have too much serotonin, you can get brain congestion and a migraine, for example, with the arteries opening up and the veins closing down. ANDREW MURRAY: Okay. RAY PEAT: So there might be serotonin inhibitors in gingko, but I think the most important benefit of ginkgo is that it’s a very good nitric oxide inhibitor. SARAH JOHANNESEN MURRAY: And also blocks platelet aggregating factor. ANDREW MURRAY: Right. It is a PAF blocker, isn’t it? RAY PEAT: Oh. And mentioning that, it blocks prostaglandins pretty generally. SARAH JOHANNESEN MURRAY: Yes. ANDREW MURRAY: And they are pro-inflammatory. RAY PEAT: Yeah. ANDREW MURRAY: Yeah. Okay. It’s 7:46 here on KMUD Garberville 91.1 FM. From now until the end of the show at 8 o’clock, you’re invited to call in if you have any questions about tonight’s show on longevity and brain foods. Number is 923- 39111. Or if you live outside the area, there’s a 1800 toll-free number which

00:46:44 > is 1800-KMUD- RAD. So to carry on with the subject of brain foods, I know we had this conversation earlier and got into a philosophical topic of the meaning or the usefulness of the determination of intelligence when it comes to marketing of brain food as supposedly increasing your intelligence. But, philosophically, in terms of what we as human beings are told by our peers and by media advertising intelligence is not x just intelligence. And there’s actually many different ways of looking at intelligence that can be useful if we don’t believe the IQ is the only determinant and if we can again not do complicated mathematics in our head that

00:47:46 > – if we can’t do that, there is something wrong with us because intelligence itself can take on many different forms and perhaps our society just doesn’t recognize or want to recognize some of those forms. RAY PEAT: The Wizard of Oz idea that maybe you can just go online and buy a diploma and become intelligent and qualified. It’s starting to look like the mechanical idea of qualification, you learn certain techniques, like computer programming, they can break it down into little credits and micro-degrees and so on, and you accumulate your qualifications in terms of what the culture has to sell. But I think the whole idea of intelligence, x it’s sort of like the wear and tear

00:48:48 > idea of aging. It’s an idea that there is a blueprint laid out for how the body develops. It’s all determined ahead of time. And the intelligence, the IQ idea is that there are certain mental skills that an intelligent person has that you can define IQ by one of the silliest kinds of IQ tests. Had questions that were simply stories that they had asked people at Oxford, I think it was, to interpret and then they had uneducated people interpret the same story. And the IQ test asks you to interpret these little short stories. And if you do it the way the Oxford graduate

00:49:50 > did, you have a high IQ. SARAH JOHANNESEN MURRAY: That is silly. ANDREW MURRAY: Oh dear. RAY PEAT: So a lot of products are being sold with the idea that if you take them, you will become clever in these ways that will make you compete in the society. But if the society is set up in an irrational way, then it’s not intelligent to succeed in terms that the society presents. ANDREW MURRAY: Yeah. That reminds of the caste system in India. I read a BBC news article just the other day about a chap in India who had 6 degrees, he had a couple of master’s degrees in various different subjects, but unfortunately, for him, he was of a certain caste. He was of a caste that actually was – I forget the name they gave them now, but they were basically a caste that was relegated to cleaning up human waste. And no matter how many

00:50:52 > degrees this chap had, and he got time off to go to university and to study for his exams, etc., and he passed one after the other. And started getting wise to him, wanting all this time off and started to try block him, but he actually just protested against and eventually he won, was given the time off to do his extra degrees, and they still wouldn’t do anything about him in terms of his social standing because they had already compartmentalized him. And that’s very much the opposite of what we talk about with environmental enrichment and the kind of things that can bring to society as a whole and also to individuals that can then affect other individuals. Pretty much a kind of brainwashing of systems of a certain type of belief. RAY PEAT: Yeah. The nootropic people are really committed to the idea of intelligence as competition. ANDREW MURRAY: Right. RAY PEAT: To gain status, but

00:51:56 > I think there is a more general idea of consciousness and intelligence that applies to life in general x that it’s an appropriateness of the way you live, which is intelligent, not the skill you have to fit into whatever you might encounter in the society. It’s the ability to decide whether you want to fit in or not. ANDREW MURRAY: I think also the quotidian here of fitting in in terms of feeling alive and well, I think, is very important. And, obviously, we’ve talked at length in the past about various toxic insults in our food supply, in our environment, what people consider normal in terms of their pass times or their free time

00:52:58 > or their occupation or just in their thoughts, and you mentioned learned helplessness and the kind of inescapable stress and the kind of events that that promotes. But just having an open and free outlook and/or, like I said, a job that not necessarily pays well, but that you really enjoy is so much more important. And in terms of IQ, as you’ve mentioned, it’s a really false – in a lot of ways,a false system of determining intelligence and that society itself is very much molded unfortunately by the huge corporations that surround us selling whatever products they have to offer. And so,when I started looking at nootropics as a pretty endless sort of list and it’s gone on from one to the next to the next, and I know that Life Extension magazine definitely promotes a lot of life promoting products. And so, there are definitely some products, of course, like you’ve mentioned –

00:54:00 > things like thyroid, things like pregnenolone, basic anti-stress chemicals, compounds that are naturally produced by the body to offset the toxic effects of stress and the inflammatory effects of stress. RAY PEAT: And vitamins are important. ANDREW MURRAY: Yeah, I was going to mention – I know you mentioned B1 and then B12 fairly realistically important anti -stress and, thereby, perhaps, memory or cognition enhancing products. SARAH JOHANNESEN MURRAY: And niacinamide. RAY PEAT: Yeah. And caffeine, if it’s used properly. But a lot of people are thinking of caffeine as a legal version of cracked cocaine and it shouldn’t be used as feed. It should be used as a food. It should decrease

00:55:02 > nitric oxide exposure, and so it should have anti-aging properties. But if you take it on an empty stomach, it will drop your blood sugar, turn on nitric oxide and cause aging stress. SARAH JOHANNESEN MURRAY: So have caffeine after you had a big meal? RAY PEAT: Yeah. ANDREW MURRAY: Yeah. I just want to bring out one particular herb just because it’s kind of pertinent to the subject of nootropic, cell performance enhancing, and it’ actually under the umbrella of the general term adaptogenics, which was coined by Russian research when they were looking at cheap alternatives to drugs that they perhaps couldn’t produce in the 50s for their space program. They were very much into looking at plant sources. And the Ginseng is, obviously, one of those kind of crowning products that you think about when you think about both longevity and enhancing mental performance, etc. But that resistance, that term adaptogen coined to describe a compound that improved the organisms’

00:56:04 > resistance to stress, so the Korean Ginseng, Panax Ginseng is one of those things, obviously, that I think of along with Eleutherococcus and several other Ginseng species. Okay, I kind of thing that is coming towards the end of the show. I think we want to just do another shout-out here. Do you want come on in? Oh, somebody is on the phone, are they? Well, we’ve got four minutes, I don’t think we can take it because it is going to push us over 8 o’clock and there will be unhappy people. But, perhaps, if they want to call in, I will take the call afterwards. Perhaps we can do that. So, thank you so much for your time, Dr. Peat. x RAY PEAT: Okay, thank you. SARAH JOHANNESEN MURRAY: Thank you and good night, Dr. Peat. RAY PEAT: Good night. ANDREW MURRAY: Okay. So I just want to let people know, in the next few minutes here, a little bit more about Dr. Peat, how they can find out about him, read his work, look at some of the other stuff that he has published, get a feel for him from the shows. Hopefully, any moment soon, perhaps in the next month, the website that we have will be updated.

00:57:06 > And it is my intention to post all of the audios that we’ve done with Dr. Peat. I think there’s getting on for 50 at least of them and publish those for people to freely download and listen to. Dr. Peat’s website, www. raypeat.com, is full of articles, fully referenced, all of his research, his own unique way of looking at all the pieces and bringing together a cohesive framework within which to understand what medicine so often tries to hit with a hammer with a single drug in large amounts or toxic drugs that have negative effects. So Dr. Peat has a very unique way of looking at things. And I know, from personal experience, a lot of what he has brought out to us has really helped a lot of people. So his website is a very good starting point to look at articles. SARAH JOHANNESEN MURRAY: And that’s

00:58:08 > www. raypeat.com. ANDREW MURRAY: And my name is Andrew Murray. SARAH JOHANNESSEN MURRAY: My name is Sarah Johannesen Murray. ANDREW MURRAY: For anybody who wants to find out anymore about us, we can be reached toll-free on 1-888- WBM-HERB, Monday through Friday. And it’s certainly becoming – on the drive in this evening, 10 to 7, I was looking at the trees and the changing colors in trees, dropping their leaves already, and just thinking, wow, it’s the 21st of August and it feels like the end of September. SARAH JOHANNESEN MURRAY: It’s all a month early this year, it seems. ANDREW MURRAY: It’s all at least a month early. Anyway, we are on the third Friday of each month, and so until the third Friday of next month, I will say good night. SARAH JOHANNESEN MURRAY: Good night. CARRIE: Yes. And good night and good evening. And this is Carrie and I just wanted to jump in here at the end of your show to say a few thank yous that just came in. Thank you to this anonymous who said Herb Doctor, info on the show is priceless. So thank you

very much. SARAH JOHANNESEN MURRAY: Thank you for that. ANDREW MURRAY: Thank you. CALLER: Yes. And another thank you. People who listen to KMUD need to pledge. That’s what Karen from Branscomb says. Thank you so much, Karen. ANDREW MURRAY: That’s the only thing that keeps the show going, right, is pledges. There’s no state money. SARAH JOHANNESSEN MURRAY:The whole station is an independent station. ANDREW MURRAY: Yeah. CARRIE: It’s a community radiostation. I believe we get some funding – outside funding. But it’s all from the – I am not sure, but it’s mostly just CARRIE: community support absolutely. ANDREW MURRAY: Which allows the radio show to be as unique as it is because perhaps there’d be more outside control. CALLER: Right. We’re completely independent that way, like federal money to support the community radio station…