00:00:00 > ANDREW MURRAY: Welcome to this month’s
00:01:02 > and this new year’s Ask Your Herb Doctor. Happy New Year, everybody. My name is Andrew Murray. For those of you who perhaps have never listened to the shows, which run every third Friday of the month from 7 till 8 PM, I'm a licensed naturopathic doctor who trained in England and graduated there with a degree in herbal medicine. We run a clinic in Garberville where I consult with clients about a wide range of conditions and recommend herbal medicine and dietary advice. So you’re listening to Ask Your Herb Doctor on KMUD Garberville 91.1 FM. And from 7:30 until the end of the show at 8 o’ clock, you’re invited to call in with any questions either related or unrelated to this month’s subject of digestion and emotion. Some of it is carrying on from last month’s topic of you are what you eat. I had quite a few people writing afterwards on that subject to get some feedback from people who had listened. So thank you for that. The number here if you live in the area is 923-3911. Or like so many people these days, if you live outside the area, the toll-free number, which is 1-800-
00:02:04 > KMUD-RAD, so that’s 1-800-568- 3723.So we’ll be taking calls live from 7:30 onwards. But until then, let’s just introduce, Dr. Peat. Dr. Peat, are you with us? RAY PEAT: Yes. ANDREW MURRAY: Hi. Thanks so much for joining us again. As always, we want to give people the benfit of understanding your professional and academic background for those who maybe have never heard of you or who’ve just tuned in, so if you’d like to just tell them your professional and academic background. RAY PEAT: After working several years in humanities areas, I decided to study biology because of wanting to get a concrete grasp of how the brain works in making language, images, and so on. So I intended to work on a Ph.D. at University of Oregon starting 1968 in brain biology.
00:03:08 > I quickly found that that was the most dogmatic area in biology, genetics and nerve biology. And so, immediately, I looked around for less dogmatic areas, and it turned out that the extreme other end of the organism, the reproductive system, happened to be the most scientific and empirical. So I did my dissertation on oxidative changes in the female reproductive system with aging. And that involves a lot of nutrition- related topics that were of interest to me. ANDREW MURRAY: I think just to let people know, at one time, you were actively consulting with people, weren't you, for quite a few years? RAY PEAT: In the 70s, I just happened to
00:04:10 > meet some women who were having hormonal problems. In graduate school, I had talked to some girls who, immediately when they came to the university, got a cheap basement apartment, started having terrible PMS. And that 1967/68, I got interested in the role of light in brain and hormone functions. And I called it winter sickness, from a light deficiency. And then, when I started running into women with – oh, a slightly older group, 40, 45 and 50, having really serious problems like multiple sclerosis and several other nerve-related
00:05:12 > conditions, I recognized the work I had been doing with hamsters and hormones as being directly applicable to them. So I started doing nutritional consulting and, finally, started suggesting that they use progesterone and thyroid supplements because, in some cases, the diet just wasn't enough to take care of acute problems. ANDREW MURRAY: Okay. And also, just so people that are listening can be aware, you produce a monthly – or is it bi-monthly now? RAY PEAT: Bi-monthly. ANDREW MURRAY: Yeah, a bimonthly newsletter. So, anyway, we’ll be giving out Dr. Peat’s information at the end of the show for people who’d like to either contact him or find out more about this website and all the articles that he has freely available and reference that. Dr. Peat, I wanted to carry on partly from last month's topic on
00:06:14 > You Are What You Eat and a little bit more of a focused look at diet, digestion, and emotion because I know that some of the things that you brought out in your most recent newsletter, as well as the prior one kind of piqued my interest in some other directions. And I also have questions from people that have been garnered since the last month that I want to – see if we can get time to put to you. Going back to last week, you mentioned this gut peptide called cholecystokinin was previously shown to have a crucial role in mediating the effects of intragastric fatty acid solutions on brain activity. And they were saying that the receptors for CCK, this cholecystokinin, are known not only for their role in digestion, but also for roles in memory function and learning and in the modulation of panic and anxiety. So there's this link between the gut and the emotions. So it's not – gut is not just for digestion and picking up food and sending
00:07:16 > it off to the various departments that store it like the fat cells, etc. But it also triggers emotive events in people. What do you interpret from my suggestion that CCK's role in the stimulation of secretion of bile in the digestion and the absorption of nutrients, especially fats, supports a link between this mental function and digestion? RAY PEAT: I think it's good to consider at least one other digestive peptide, the gastric inhibitory polypeptide, GIP. ANDREW MURRAY: Okay. RAY PEAT: My general picture of the organism, for example, analogous to the sympathetic nervous system and the parasympathetic nervous system, the day and the night sides of the nervous system. Everywhere you look, you can see this sort of a polar opposition in two kinds of functions. One is
00:08:18 > mobilizing, the other is demobilizing and relaxing. ANDREW MURRAY: Okay. That's a parasympathetic, so the relaxing and the mobilizing is sympathetic. RAY PEAT: Yeah. When the organism is young and healthy, that opposition works very nicely for night and day action and rest, cycling. In the digestive system, when you eat fats and proteins, you secrete the cholecystokinin. When you eat sugar, you secrete the GIP, which is also called the insulinotropic hormone because it calms down, stops your acid digestion because you don't need acid to handle sugar, but it activates the insulin, so that you handle the sugar. When you look at the
00:09:20 > effect in the brain, CCK activates the Corticotropic Release Hormone, which turns on anxiety and stress and the pituitary ACTH which turns on the adrenals to handle stress. And the gastric inhibitory peptide responding to glucose has pretty much the opposite effects. And in the hippocampus, for example, which is a part of the brain that's expanded by opportunity and learning and shrunken by stress, the insulinotropic hormone, responding to sugar, also has receptors
00:10:22 > in the hippocampus that stimulates the birth of new cells. So learning and stimulating experience and eating sugar have… ANDREW MURRAY: Go hand in hand, eh? RAY PEAT: Yeah, the same effect on your brain. Eating fat and protein, surprisingly, turn on anxiety and stress. ANDREW MURRAY: Even protein, huh? RAY PEAT: Well, yeah. That tends to lower your blood sugar because it also stimulates insulin. ANDREW MURRAY: Got it RAY PEAT: And lowering the blood sugar turns on stress. ANDREW MURRAY: Okay. RAY PEAT: And in the further-down intestine, if you could be born without bacteria – they've created situations with cesarean birth of rats and dogs and pigs and such and
00:11:24 > keeping them in a germ-free environment, they find that everything develops perfectly. In fact, the animals live longer and are very resistant to obesity and diabetes and degenerative diseases.ANDREW MURRAY: Okay. They have a very high metabolic rate, too, don't they? RAY PEAT: Yeah, they're very much like the calorie- restricted animals. And fat-free diets, where they don't have the so-called essential fatty acids, those animals have an extremely high metabolic rate, too. And so, the calorie restriction and being free of germs both stimulate your ability to oxidize food, produce energy, and
00:12:26 > prevent obesity and be generally healthy and long-lived. So, something is happening in the intestine that the bacteria are responsible for. And the main thing, it turns out, that the bacteria are doing is usually converting starch. Starch is the main bacteria- promoting food. The bacteria living on these foods that we don't digest produce endotoxin. And the endotoxin, everywhere it reaches, a human cell stimulates the production of nitric oxide. And nitric oxide, it’s on the demobilizing side of
00:13:28 > the balance. It turns off metabolism, slows down oxidation. ANDREW MURRAY: Okay. RAY PEAT: So it's the main reason that having too many bacteria in the intestine creates obesity and lethargy and short life. ANDREW MURRAY: Is it all forms of starch that will promote the endotoxin production or…? RAY PEAT: No. If they are very well cooked and easy to digest and aren't complex with fibrous material – the difference would be a corn tortilla that had been processed in alkali to open up the starch granules… ANDREW MURRAY: Okay. RAY PEAT: …making them easy to digest versus the bean carbohydrates, the type of polysaccharide that human enzymes can't work on are ideal for feeding bacteria. ANDREW MURRAY: Hence all the
00:14:30 > gas. RAY PEAT: Yeah. ANDREW MURRAY: That’s not good for you, folks. RAY PEAT: When they've experimented with rats on this type of soluble indigestible fiber, the ones that get the fiber that supports bacterial growth become anxious and aggressive. They're fearful, and so they fight too easily. ANDREW MURRAY: All right. So there’s a definite connection there. Let me just put your information out for a moment here, Dr. Peat. So welcome to this month’s Ask Your Herb Doctor. You’re listening to Ask Your Herb Doctor on KMUD Garberville 91.1 FM. And from 7:30 until the end of the show at 8 o’ clock, you’re invited to call in with any questions either related or unrelated to this month’s subject of digestion and emotion. We have Dr. Raymond Peat with us in the studio. We’ll be taking calls from 7:30 till 8 o’clock. So, Dr. Peat, okay, you've looked at and interpreted the link, then, between
00:15:32 > sort of decreased mental performance and poor digestion with the endotoxin formation, especially from starch. I'm glad you brought up nitric oxide because, again, when I was looking up some articles this afternoon, I think you need to bring this out as a fairly important point because I think just like sugar and just like polyunsaturates, both of which – well, sugar was demonized and polyunsaturated fats were promoted, so the liquid oils, the polyunsaturates, are now definitely swinging in the other way .Even medical opinion is of the mindset now that maybe saturated fats are actually much better for the cells, much more stable, and more health promoting than the polyunsaturates, but it's taken a long time. And maybe, I think, sugar perhaps in time will come around again. But it seems, at the moment, that nitric oxide is a pretty prevalent supplement. Or rather, the l-arginine that nitric oxide is manufactured from is becoming a fairly popular supplement, especially in the body building
00:16:34 > world. And I wanted to ask you, given that these things are so freely available, and publications – numerous publications – even so-called scientific journals are coming out with studies that support nitric oxide's importance and saying that it's extremely important for endothelial health. So the inner lining of the arteries, arterioles, etc. is the endothelia, and nitric oxide is produced within that to prevent things like stroke, angina, and a whole other host of cardiac events that would be considered causative without nitric oxide in terms of the kind of starvation, as it were, because the vasoconstriction that would happen, because nitric oxide is a vasodilator, but yet there's so much evidence contrary to that, and that's what I'd like you to bring out. Why is nitric oxide so dangerous because I know it's been implicated in stroke in people who used Viagra, for example?
00:17:36 > RAY PEAT: Yeah. I just recently heard about a doctor who treats cancer patients with intravenous arginine. Just before I heard about him , I had been reading way back to the 1940s, people discovered that arginine stimulate cancer growth, and starvation or a reduction of arginine stops cancer growth. And through the 50s and 60s, continuing – it's being picked up again just recently – methods to stop the conversion of arginine to nitric oxide or to reduce the availability of arginine.It's being investigated, again, as a way to cure cancer. So there are these two very opposite things going on. One, nitric oxide
00:18:38 > is being proposed to cure cancer; or suppressing nitric oxide, it's demonstrated to stop the growth of cancer. And the first things that I was hearing about nitric oxide, I happened to be interested in endogenous carbon monoxide in the early and mid-80s. And it can promote cancer by blocking the respiratory enzymes. And then, in the mid and late 80s, people started realizing that something was producing nitric oxide in the body. I think it was '88 or '89 when the enzyme was demonstrated – we actually have the enzyme that makes this smog- like free radical in our tissues.
00:19:40 > And because it was already known as a major toxin in smog, immediately, people were investigating what it's really doing in the body. And from about 1990 up until the middle 90s, there are many publications showing that, very clearly, nitric oxide produced in the pancreas kills insulin-producing beta cells. That was just massively documented up until about '96. Then, the Viagra people, they got a patent and started promoting the idea that somehow nitric oxide is associated with virility. And suddenly the research, by the late 90s, was turning
00:20:42 > just 180 degrees, saying everything that nitric does must be wonderful because it is related to male virility. ANDREW MURRAY: Now, am I right in thinking also that nitric oxide in smog is a causative agent for asthma? RAY PEAT: Yeah. And there are people recommending arginine and breathing nitric oxide to treat asthma, but others demonstrating that people with asthma are producing it themselves, so you can measure it in their breath. The worse their asthma is, the more nitric oxide comes out in their breath. It's the same with hepatitis, cancer, any major systemic disease.You can find increased amounts of nitric oxide related chemicals in the blood. ANDREW MURRAY: Interesting. I'm glad you mentioned that. Because I’ve got a question from a couple of other people that I want to ask you in a
00:21:44 > bit about that subject. But let me just go back because nitric oxide is – okay, here’s the deal. Nitric oxide is produced in the body and supposedly has beneficial functions. So what do you think about the beneficial function of nitric oxide in the body and how is that mediated to a point where it's not dangerous, as it is if you're looking at being exposed to it or taking arginine to produce it in your body more than your body does. What’s its real benefit? RAY PEAT: It helps cells to de-differentiate by blocking their energy production. If you think of the mitochondrial high-energy oxidative system as being what creates a complex organism that uses energy so efficiently, it can have many different types of tissue. If you want to de-differentiate, produce a stem cell, you
00:22:46 > knock out the energy production and it goes back and becomes amoeba like or fungus like. ANDREW MURRAY: So this is like a stem cell recruitment... RAY PEAT: Yeah. When a tissue is injured, it secretes a great burst of nitric oxide, and that calls up stem cells from the environment, but it also creates them .It de-differentiates adjoining tissues, so that they can form whatever new tissue is needed. So de-differentiation is part of forming the organism in the first place as the embryo develops. Nitric oxide has a constructive role. And then for tissue – wound healing, it's essential. But that very same burst that calls up repair cells and de-differentiates cells to make repair
00:23:48 > cells, if that doesn't have the ability to be turned off, it keeps de-differentiating and stimulating tissue renewal, so that you get an unhealing wound. The least bad example of that would be a keloid, a scar tissue that just keeps growing and getting bigger without forming the right kind of tissue. But, in the worst case, then it becomes a tumor and a cancer. ANDREW MURRAY: So how do you – do you see the control – how do you see the control of nitric oxide, so that it's a proportionate response if and when you need it through injury, and blocking it dietarily or supplementaly, so that you're not exposed to this pretty dangerous compound at all until such a time as your body might need it for whatever reason? RAY PEAT: Everything that
00:24:50 > we have that is involved in producing oxidative energy helps to turn it off. So vitamin B1, niacinamide, the anti-inflammatory things like progesterone and pregnenolone, thyroid hormone, all of the differentiating, mobilizing, energy- intensifying substances turn it off. And everything that interferes with those turns it on and keeps it going. So it's the demobilizing – for example, going into hibernation, an animal produces these demobilizing signals with nitric oxide. And anything that makes the organism tend to give up and stop struggling,
00:25:52 > demobilizing because of stress or isolation. Inescapable stress powerfully turns on nitric oxide. So in the brain function, when your brain is being turned off, it experiences depression. It wants to retreat. And things like anxiety and aggression, you aggress if someone doesn't let you retreat. ANDREW MURRAY: I wanted to ask you about the mind- body connection because I know that when I've spoken to you previously, you're kind of advocating what I think a lot of kind of new age or alternative thinking people would have held as a tenet of their belief in sort of a higher power, if you like. Through focused attention and positive thinking, your
00:26:54 > physical body can definitely be improved. And I know I've had this conversation with you previously about.Well, what would come first? Would you use supplements that will promote everything that we've been talking about now, so progesterone, thyroid, the B vitamins, etc. to turn this negative cascade off?Or would you have a positive mental outlook? Or do you see the two being as important together and do you have any kind of protocol that you would be looking at that would be a good rationale for achieving both of those things? RAY PEAT: When you look at the example of the psychologists who create depression by torturing animals, convincing them that they can't escape, once they form the idea that they can't escape, they don't try to escape anymore. So it's an intellectual switch that happens
00:27:56 > from the bad experience. And if you have made an animal helpless by those experiences, just one experience of escape will cure it. ANDREW MURRAY: It will have the knowledge. RAY PEAT: Yeah. It's resistant because of that knowledge. The culture is telling people too often that they can't escape. They have to do what they have to do. ANDREW MURRAY: Yeah. Put up and shut up RAY PEAT: Yeah. So something as simple as taking a vacation or getting a new job can make a tremendous difference.A person can pop right out of a prolonged depression if they get a new kind of work, for example. ANDREW MURRAY: Let me just hold your train of thought, Dr. Peat. We’ve got the first caller of the evening. So let’s take this caller and see where they’re going. Caller, you’re on the air
00:28:58 > and where are you from? CALLER: I'm from Kansas City. ANDREW MURRAY: Kansas City. Hi. Go ahead. CALLER: Yeah. My question for Dr. Peat is, do you think using low-dose Arimidex as aromatase inhibitor would be appropriate for a female who is correcting her metabolic rate by a thyroid diet, but has a fair amount of fat to lose still. Would that be safe to use while she loses the fat safely? RAY PEAT: Those chemicals all have some side-effects, so there are much better ways to turn off estrogen production. Just the end otoxin from bacteria is a powerful promoter of aromatase and estrogen production. And so, taking an antibiotic or eating a kind of fiber that doesn't support bacterial growth or avoiding starches and eating saturated fats, which have a germicidal effect –
00:30:00 > saturated fatty acids are very much like antiseptics as far as the intestinal bacteria go. So just by making those dietary changes, you can make a tremendous impact on your balance between estrogen and cortisol versus the protective progesterone and androgens and so on. CALLER: Okay, that sounds good. I had one more question. Could you just explain briefly the mechanisms of histamine and the good ways to correct that? RAY PEAT: Histamine and ways to what? CALLER: Just ways to correct someone who has this histamine responses periodically. RAY PEAT: Since I was mentioning the saturated fats, some of the shorter chain saturated fats in coconut oil have an anti-histamine effect. Coffee
00:31:02 > is a very effective signal to turn off histamine production. Anything that energizes and restores cell function tends to prevent the production of histamine. ANDREW MURRAY: How about sugar? RAY PEAT: Oh, definitely. A person wrote a book about histamine about 40 years ago and he demonstrated that histamine is produced in every kind of cell in an organism when it's sufficiently stressed. And that was before nitric oxide was known, but histamine turns on nitric oxide.So those are the two probably universal stress injury signals. ANDREW MURRAY:Okay, great. We do have another caller that’s just come in. So let’s take this next caller. Hi, caller. You’re on the air. And where are you from?
00:32:04 > CALLER: Yes. Andrew, this is David in Missouri ANDREW MURRAY: Hi, David. CALLER: On the last show, we were talking about the bacteria in the intestine. And you had mentioned that, a lot of times, tetracycline will be used and it will kill – I don’t remember the exact wording, but it was something to the extent that the harmful bacteria are killed and the beneficial survive. Do we know that for sure? Like, if you’re using something like tetracycline, does this pretty much – depending on the dose, does it kill most of the bacteria? And how does it selectively spare the, what we would call, beneficial? And I guess, along the same lines there, I've always heard that there is kind of a symbiotic relationship with certain intestinal bacteria that help to absorb certain nutrients.
00:33:06 > And so, I'm assuming that would be considered a beneficial bacteria if that is true. RAY PEAT: I think the interactions of the intestinal bacteria are too complicated to divide them neatly into beneficial and harmful. In the germ-free animals, they've done experiments with introducing a single species of lactobacillus, and even the supposedly beneficial bacteria will make the germ-free animal susceptible to injury that it wasn't susceptible to before. So, it's the context and interaction of the different bacteria, and generally the healthier a person is, the more sterile their small intestine is. CALLER: Okay, interesting.
00:34:08 > So, what do you think of the idea that certain nutrients are absorbed through the actions of so-called beneficial bacteria? Is that kind of a fallacy or…? RAY PEAT: Yeah. I think it's – there's a little effect there, but I don't think it makes a big nutritional difference. The totally germ-free animals had extremely efficient digestive systems. CALLER: I’ve heard you say that. I was just curious because you still hear this being talked about all the time, like this is beneficial bacteria.And, of course, I know people are selling beneficial bacteria, so that’s part of the reason that’s being done, I'm sure. The other thing I wanted to ask you is, the term free fatty acids, is that always referring to polyunsaturated fat or is there instances
00:35:10 > where free fatty acids are actually saturated fat? RAY PEAT: They can be either way. Coconut soap is the salt of the saturated free fatty acids. And so, if you actually could eat a bite of free fatty acids, it would taste like acidic soap. CALLER: Interesting. ANDREW MURRAY: We do also have a couple of callers also. So let’s wrap this one up. CALLER: Okay. Okay, thank you. ANDREW MURRAY: Yeah. Thanks for your call. So let’s get this next caller on the air. We’ve got two more. So let’s take this next one. Where are you from? CALLER: Hi. I’m Kim from Garberville. ANDREW MURRAY: Hi. Welcome to the show. CALLER: Thank you. So I just had a question, I was wondering what the effect of infrared, like sauna, would have on the cell, mitochondria. It produces nitric oxide, doesn't it? ANDREW MURRAY: Dr. Peat, what do you think of infrared in terms of a possible nitric oxide
00:36:12 > production from the mitochondria? RAY PEAT: Water absorbs infrared very powerfully. And so, real infrared feels warm and it helps to keep your body temperature up.And keeping your body temperature up is very good, essential for the mitochondria. The stress of cold is enough to turn on nitric oxide. And that can start down the pathway of hibernation and turning off functions. So, infrared, as it keeps your body temperature up, helps your mitochondria. The far- red visible light – dark red, anywhere from orange to dark red – these aren't very well absorbed by water, and so they go right through your tissue. You can see a red light shining through your whole
00:37:14 > body if you're in the dark. You can see it through your hand. Put a light behind your hand. That's because it penetrates and is only is absorbed by – blue copper is the main thing that absorbs it. Enzymes that contain copper in the blue form, that does absorb red. And those happen to be the respiratory enzymes. And so, the far-red activates the respiratory enzymes.And probably a major reason for that is that it bounces the nitric oxide molecule, loosens it and frees it from the respiratory enzymes where it has been blocking it. ANDREW MURRAY: Interesting. CALLER: So that’s beneficial? RAY PEAT: Yeah. ANDREW MURRAY: Yeah. CALLER: All right. Thank you so much. ANDREW MURRAY: You’re welcome. Okay. We’ve got two more callers still. Another one called in while the first
00:38:16 > one’s on hold. So let’s take this next caller. You’re on the air. And where are you from? CALLER: Hi. I'm calling from Sacramento. ANDREW MURRAY: Okay. Welcome to the show. And what’s your question. CALLER: This is related to what Dr. Peat said about treating corn with alkali – or lime,rather, to make it more digestible.And I was wondering, do sprouted grain tortillas, are they also considered good for digestion? ANDREW MURRAY: Dr. Peat, sprouted grain? RAY PEAT: Starch is largely consumed and used. The storage proteins in the seed happen to have lots of ammonia or amino groups which are used to make actual functioning proteins with the energy from the starch. And so, when you sprout a grain, you get rid of the toxic
00:39:18 > proteins that could release too much arginine and produce nitric oxide and histamine and you get rid of most of the starches. So sprouts are basically good nutrition, like leaves. CALLER: Oh, great! So it doesn't matter whether it is sprouted wheat or barley or whatever? In general, it's a good thing? ANDREW MURRAY: Dr. Peat, did you hear that? RAY PEAT: No. ANDREW MURRAY: The gentleman asked, it didn’t matter whether it was wheat or barley, that generally sprouted things were a good thing. Did you hear what I said or is there a problem with the line at the moment? RAY PEAT: Yeah, the line is getting a little garbled. ANDREW MURRAY: Okay. The gentleman wanted to know if all sprouted things were beneficial because of how – what they went through.
00:40:20 > RAY PEAT: All seeds, as far as I know, have some toxic effects. Many of them are built in by the plantto protect their offspring. And once the sprouting has begun, the seed detoxifies those intrinsic chemicals, especially if it's very well cooked, and then it becomes nutritious. ANDREW MURRAY: Okay. So I think to answer your question then, caller, the activity of sprouting neutralizes the defensive compounds that are in the seeds originally. So I think the answer would be yes. Most sprouted items would be beneficial and nutritional for you. CALLER: Oh, great! Thank you. One final question, if I may. ANDREW MURRAY: Okay, quickly. CALLER: Progesterone for men, is it beneficial or harmful? ANDREW MURRAY: Dr. Peat, did you hear that? RAY PEAT: Oh, yes. The men
00:41:22 > who are in good health have a fair amount of progesterone. It's rarely measured in men, but it prevents abnormal excess clotting and it's a precursor for other hormones. But if you have a good amount of progesterone, it protects you against fluctuations in the adrenal steroids – aldosterone and cortisol – so that progesterone is sort of an all-purpose defensive hormone. It's very highly concentrated in the brain, men as well as women. So it's definitely not just a female hormone. But if you have too much of it - if you take a supplement, it opposes testosterone,
00:42:24 > and so a man doesn't want to take it regularly and stop his whiskers growing, for example. But for an emergency, a big supplement can be helpful for – for example, epilepsy or arthritis, it's very helpful for men as well as women. ANDREW MURRAY: Sorry to interrupt you for a second, Dr. Peat. How quickly would you metabolize a dose of progesterone if you did take it and it was a large dose for something that was...? RAY PEAT: I know a doctor who insisted that taking progesterone orally wouldn't show up in the blood. So he took a 1/4th of a teaspoon and then drew his blood every half hour for 12 hours, I think, and he showed that it peaked
00:43:26 > in around the first hour and then gradually decreased over the next day. ANDREW MURRAY: Okay. All right. So within 24 hours or so. Okay, we have another call still waiting here. So let’s take this next caller. Caller, you’re on the air. CALLER: Hi. ANDREW MURRAY: Where are you from? CALLER: Garberville. ANDREW MURRAY: Oh, you’re in Garberville too. Okay, go ahead. What’s your question? CALLER: Well, thank you again for a wonderful show. A lot of wonderful information. There was one thing that another caller mentioned about, beneficial bacteria. Is it the doctor’s opinion there or your opinion as well that yogurt or its supposed beneficials is not so beneficial? RAY PEAT: If it has had some of the lactic acid drained off or if it has just coagulated without becoming very sour, then it's fine.
00:44:28 > CALLER: Is there a difference then between, like, a Greek yogurt and a goat milk yogurt or is…? RAY PEAT: Yeah. I think the Greek, which isn't sour, is safe, but the very acidic ones and related products – I discovered that by drinking a cup of Kefir – every day, I would have a cup of that for lunch. I would get a migraine for several hours afterward, and so I started reading about what's happening. And for one thing, the type of lactic acid produced by bacteria is racemic. And the kind we make is mostly the one confirmation that works differently. And the racemic type made by bacteria is more able to
00:45:30 > produce inflammation and fibrosis if you’re chronically overloaded with it. CALLER: Really! That actually dovetails nicely into my main question, I think. I was recently more or less diagnosed, by a Western style doctor, with a particular type of skin condition that I've been suffering with for 20 years or so, Hidradenitis suppurativa, supposedly something that deals with the apocrine glands, it’s a type of sweat glands that causes cysts. So do you have any info on that?And when you're talking about yogurt and the inflammation caused by certain bacteria, I've been actually trying to support my system in general with – well, Kefir, you mentioned that and [inaudible].
00:46:34 > RAY PEAT: People have experimented with even killing the lactobacillus.And it in itself, even when it's dead, it has a very definite anti- inflammatory effect in the intestine. CALLER: Anti-inflammatory? So it would be a good thing then for a condition that causes inflammation and cysting? RAY PEAT: Yeah, that seems to be the implication that it isn't the lactic acid or the metabolism of the lactic acid bacteria that is anti-inflammatory, but just something about the chemistry of the organism, even if it's dead. And since the inflammation in the intestine is quickly reflected in the physiology
00:47:36 > of the skin, soothing your intestine will take care of a lot of skin conditions, acne... CALLER: So you're saying the bacteria itself is beneficial, but not the lactic acid that is common with many sour yogurts RAY PEAT: Yes. So yogurt minus the lactic acid is better. CALLER: Awesome. Well, thank you very much. ANDREW MURRAY: All right. Thank you for your call. Okay. If anybody else is listening and wants to get a question or two in before the end of the show at 8 o’ clock, the number if you’re in the area is 923-3911. Or there’s a toll-free number, which is 1-800- 568- 3723. That;s 1-800- KMUD-RAD. Okay. So, Dr. Peat, just if perhaps we’ve got the time, I guess these are questions that I’ve had put to you anyway. I'm glad that we’ve had some of these questions surrounding
00:48:38 > what you’ve been talking about and not something completely different. That’s always very useful to have people newly challenged, if you like. So I wanted to ask you that from a perspective of kind of Hippocratic medicine,they always mention that the liver was the seat of anger. Do you have any comment on how this might come about? It might be related to digestion and endotoxin and inflammation. What do you think about that? Does that make any sense or do you think it’s just…? RAY PEAT: The liver, to the extent that it's injured, will ruin the whole organism. It's the chemist for the whole organism. And if you’re starving and not getting enough protein especially, or not enough B-vitamins, your liver loses the ability to detoxify
00:49:40 > and you get gross hormone imbalances. And that can lead to progressive inflammation, fibrosis.And as these processes get more serious, the liver becomes a larger source of nitric oxide. And at the point that it's becoming inflamed and cirrhotic, then it starts secreting nitric oxide to the whole system. And the lungs – with an acute injury to the liver, the lungs will become acutely inflamed. When they transplant a liver, they've measured the sick person's nitric oxide very high. When they put in a new liver, suddenly the nitric oxide
00:50:42 > is low and the lungs suddenly begin working more efficiently, demonstrating that the liver is poisoning the lungs, so that the oxygen doesn't get through efficiently. With the brain, the same thing is happening. Edema is produced in the brain by the e ndotoxin/nitric oxide combination. And the ammonia produced by the liver, which is being injured, was a traditional explanation for why the brain has problems in proportion to the liver. But now it's known that ammonia is activating the nerves that are excited by the glutamic acid – MSG, excitatory
00:51:44 > amino acids – and those excitatory amino acids act largely through nitric oxide. And so depression, anxiety, and I assume aggression is part of this mixture of gradual poisoning to different degrees. ANDREW MURRAY: Interesting. Do you know if there's any blood tests for nitric oxide, like there is for cholesterol or any other compounds that are fairly common if you’ve heard of that? RAY PEAT: I don't know what labs have available. It's becoming very common in research to look at the whole range of things produced by nitric oxide, but I don't know of any local medical labs that do that. ANDREW MURRAY: Okay. Well, I have another question. It’s a little bit different from all of the others. But, nonetheless,
00:52:46 > in terms of well-being, emotional well-being being restorative and kind of dynamic process that is going to improve the general health of an organism when their mind's in that place of emotionally being satisfied, happy, having a positive outlook, positive thinking, etc. Exercise, I know – in my younger days – I sound like an old person now. But in my younger days, when I used to go the gym, I remember feeling really very positive about it. Looking back on it now, it was probably because I was running on a lot of adrenaline from working out and just charging around like a crazy person. But in terms of exercise, I know that you always advocate gentle weight-bearing exercise. You don't advocate any aerobic exercise. In terms of generating
00:53:48 > a healthy physique with exercise, what would you suggest rather than protein shakes and amino acids and supplements? What would you suggest as being some of the best food sources?And perhaps – maybe you've mentioned gelatin, I don't know if you think that gelatin is a good thing because of the amino acids and what would you suggest? RAY PEAT: Gelatin is at least safe. It doesn't stimulate muscle growth the way other proteins such as meat can do. But the person's history really has to be taken into account when you're looking at the diet and the exercise program because I've known people who ate gigantic amounts of meat and were producing so much cortisol in response to the meat that they had extremely high levels of amino acids in their urine,
00:54:50 > and their muscles were being damaged by that same high level of cortisol. So ideally, like the germ free animals, they can run on very little protein and lots of carbohydrate. The carbohydrate gets used for energy and you would assimilate, essentially, all of the protein that you eat because your cortisol wouldn't be destroying it and excreting it. ANDREW MURRAY: Interesting. Well, what kind of carbohydrates that wouldn't be starchy and dangerous? RAY PEAT: Fruit. ANDREW MURRAY: Fruits, yes. Yeah. All right, so that's it. Pretty much, then, you're saying that fruit would be a very good source of amino acids as muscle building compounds. RAY PEAT: As long as you’re getting all of the essential nutrients – for example, from sea foods and eggs and
00:55:52 > fruits and gelatin – would be a very safe diet for adults. ANDREW MURRAY: Okay, very good. Well, I know we’ve got four minutes left. That’s probably not too long to go too much further without having trouble with the engineer and the next person on the show. So I do thank you for your time, Dr. Peat, once more and let me give out your information to people who have listened. RAY PEAT: Okay, thank you. ANDREW MURRAY: Okay, thanks so much. Okay. So, Dr. Raymond Peat, is viewable – if that’s the right word – on the Web, www.raypeat.com. Has a wealth of articles on links on the homepage, all of which are fully referenced and very scholarly articles. Some people might find them a little hard reading because they are pretty technical. But there’s a lot of information in there that if you want to start delving into some
of it, on the Web, you can find out quite a bit about what he’s saying in terms of the descriptive terms that might be used. But very good articles. Like, I said, well referenced and well researched. That’s his job and that’s what he’s spent the last 25, 30 years doing. So www.raypeat.com. For people who’d want to contact me, Monday through Friday, I have a toll-free number, 1-888-WBM-HERB. Let’s see what else we’ve got. Couple of minutes here. I don’t think – I'll just close the show by thanking you for your time. And until February – the third Friday in February of next month, wish you a Happy New Year again. Good night.