Herb Doctors - Endocrincology Part 3

Audio | Ray Peat

ANDREW MURRAY

: Well, welcome to this month's live Ask Your Herb Doctor. Sarah's not with us tonight. She's well but she's not with us so we're doing the show with Dr. Peat as a regular guest this evening and continuing the last two months' topic of the endocrine system. I'd like to break at some point during the show and intersperse some questions that we've had from people that have been emailed to us who, for one reason or another, can't get Dr. Peat by email or whatever but they're corresponding through me and I'm posing these questions this evening and also there is a latest newsletter from Dr. Peat. For those of you who don't know, Dr. Peat does a monthly newsletter. I think it was bi-monthly, Dr. Peat might correct me when he comes on, but I think it's a monthly newsletter that he does. So for those people, as always, who are interested in his work, there's lots of information that can be found on the web now, I've been amazed at how the web has exploded the availability of knowledge in all areas and Dr. Peat and his discussions with various different people from politics to science and health are available all over the internet, as are these broadcast and recorded programs I've found on the internet myself. Didn't even know they were there up until about a year ago but there's probably 60 or so YouTube shows of this done on the internet. So, for people that want to hear more, and they're titled by topic, you can just go to the internet, go to YouTube, and type in Dr. Ray Peat or Ray Peat Andrew Murray KMUD and also on our website, I have a full archive up until 2015. It's not as full as it could be. I've got 2016's and a few of this year's so there's probably another 16 or 17 shows that have yet to get put up, but I will endeavor to get those done fairly soon. For people that haven't really heard about Dr. Peat, we always get new listeners and from time to time we get people that don't know anything about what he's advocating and for them there's plenty of information either on the internet, by typing in Dr. Ray Peat or going to our website, which is WesternBotanicalMedicine.com and looking at the resources tab on the right hand side and dropping it down to Ask Your Herb Doctor. And also there's plenty of literature that Dr. Peat has published himself. So, he does a newsletter, and without going on too much about the newsletter, this month's newsletter is right up our street as far as I'm concerned. It's a kind of continuation and expose of covert but now disclosed somewhat CIA and other foundational groups that basically are certainly ruling, if you like, the top tier of society and molding and coercing the system to follow its edicts, and obviously that comes with a lot of tyranny. Most people that listen to this show as an alternative show would probably agree that there certainly is a tyranny at large and to resist tyranny, I think, is a call to arms, not necessarily with violence and guns but to resist tyranny by immersing yourself in alternative education, and the knowledge of that education is a powerful weapon against the tyrants who would tell us otherwise. So Dr. Peat, are you with us?

RAY PEAT: Yep.

ANDREW MURRAY: Okay. Well, thanks so much for your time on the show. Like I said, we'll go through what I'd like to ask you about with regards to the endocrine system and then there are some questions posed by callers.

As always, people who are listening, the number that we open up from 7: 30 til 8

: 00 PM for callers to ask questions directly to Dr. Peat, there's a 800 number, which is 1800-KMUD-RAD. And then there's the regular number, which I'll make sure is not changed, but it's 923-3911. So that is local area code 707 number. So, 707-923-3911, or if you're out of the area, or in Australia, (laughs) well, not for Australians. I guess they can't use the 800 number, but they're on the internet, so we can reached through the internet, too, but there's an 800 number, which is 1800-568-

3723 and we take callers from 7: 30 on to the end of the show, 8

: 00. So, Dr. Peat, I guess without further ado, I'd... Sort of where we left off last month, and we'd just, just got started into the hypothalamus and I brought up one of the things that struck me as kind of unusual, but I wanted to ask you a little bit more about it. So, from last month, breaking the question, what is a hormone and how the endocrine system regulates metabolism, you discussed thyrotropin-releasing hormone which stimulates TSH from the anterior pituitary as well as prolactin. Now, prolactin is a hormone that's responsible for lactation in females, and so is there another mechanism perhaps to satisfy TSH production in low thyroid individuals to up-regulate their T4 production which does not result in increased prolactin production? So, for those of you who are listening perhaps, the TSH is a thyroid stimulating hormone and this is basically stimulated at the same time as prolactin is. So, in low thyroid individuals, my question to you, Dr. Peat, is, the potential for women to be exposed to higher levels than normal of prolactin, and have you known women that would lactate when they weren't nursing or outside of, well, not outside of menstruation, but when women weren't fertile or nursing? Is this something that you've actually found?

RAY PEAT: Yeah, probably maybe a hundred women that I've talked to who were simply, hypothyroidism was their basic problem, but unwelcome lactation was just one of their symptoms, and usually there were menstrual irregularities at the same time, either too much or too little menstruation, and just correcting their thyroid function took care of the lactation and menstruation both. And what it's doing, it's... Partly it's regulating oxygen metabolism so that you can use your fuel very efficiently, keep your blood sugar steady so that you don't experience stress. Estrogen is, in good health, it's produced for about 12 hours once a month in a big surge, to basically create tissue stress to stir up cell division to prepare the uterus and the breasts and other tissues, pituitary, are the main things that are activated by estrogen. Low thyroid, by letting you get low blood sugar inappropriately, at the same time, it's activating the stress hormones and inactivating the parts of the liver that are normally destroying estrogen as soon as estrogen reaches the liver. Normally the small amount of estrogen being produced under moderate stress is kept very low by an active liver when the thyroid is activating the liver.

ANDREW MURRAY: Okay.

RAY PEAT: When the thyroid is low, estrogen tends to rise, and both of these tend to create an oxygen deficiency and a glucose deficiency. One intensifies the other. And these are the first step in any kind of stress reaction, and the stress reaction turns on your pituitary as a way to organize the adaptive system of the body, and the prolactin, in fish, prolactin regulates salt and water metabolism, and mammals have the various components of milk formation involving both the flow of water and salts, but including proteins, and sugar, and such. So prolactin, in all animals, has a range of anti-stress functions and lactation is just a useful component for handling the stress of pregnancy fertility.

ANDREW MURRAY: I picked up on what you said about estrogen being a, a once-monthly, a 12-hour period, a once-

monthly surge, but I just want to ask you this: It seems a very ubiquitous poison, for want of a better word, that women are continually subjected to. How can you compare that to the background levels of estrogen that you are always advising women to protect themselves from, either environmentally or with things like pregnenolone or progesterone if they have excessive inflammation going on in their body from different causes?

RAY PEAT: Any tissue of your body that is stressed will start to produce estrogen. It's a very basic reaction to stress, and so, with aging for example, when you've lost some of your basic anti-stress hormones, thyroid, and progesterone, and pregnenolone, then all of your tissues are suffering from oxygen and glucose bad metabolism. They're simply not interacting properly and that means that all of your tissues will begin producing a little bit of estrogen. For example, the post-menopausal breast tissue is producing several times more estrogen than it does during menstruation.

ANDREW MURRAY: Interesting.

RAY PEAT: And, if the liver slows down because the thyroid is low, then that little bit that's being produced by any stressed tissue is going to pile up in the blood because it should be eliminated constantly through the liver and kidney.

ANDREW MURRAY: Interesting. This brings me back to some of the research I wanted to cover, some of this endocrine stuff, with you is that, I think, and it's a little bit tied into your newsletter funnily enough, like a lot of things do. In terms of the brainwashing that science has been guilty of, brainwashing the public into deceiving them to believe that things are a certain way when actually there's previous research that showed exactly the opposite that's been buried, it's been closed up, and money's been diverted away from it and diverted towards the wanted information. So again, when I was studying, I was under the impression that basically the ovaries were the main estrogen secreting organ in the female body and that really men didn't really have estrogen. It wasn't, men had testosterone and females had estrogen, things were fairly simple, but actually it's really very different from that and hearing that, I think you said any cell, can essentially secrete estrogen in response to stress and inflammation.

RAY PEAT: Yeah, and old men get low testosterone because their stress tissue is turning it quickly into estrogen.

ANDREW MURRAY: Right, this is aromatization, right?

RAY PEAT: Yeah, and a younger man who is very sick or has an accident will have very high estrogen and that will bring up usually prolactin and growth hormone, and a lot of adaptive secondary hormones.

ANDREW MURRAY: Interesting, so I think hopefully by continuing, some other little tidbits will come out that people will pick up on and maybe start looking into things further themselves. I wanted again just to get back briefly to that first question about lactation and prolactin being secreted in females and actually causing some milk production. I wanted to ask that, is it a quantitative issue where there's not enough prolactin being stimulated by the release of TRH, or is oxytocin, for example, a more powerful stimulator of lactation?

RAY PEAT: Oxytocin really is just to release the milk once it's formed. It isn't involved directly in forming it--

ANDREW MURRAY: Right, it's a suckling response almost.

RAY PEAT: When I was a little kid during the Depression, there were very poor people moving into southern California and some of them were finding jobs and one family we knew, the mother was able to find a job when they had a baby that was a few months old, and the father, they had been starving for years, and the father was able to lactate to nurse the baby while the mother was at work.

ANDREW MURRAY: Wow. Do you see any different, out of interest, do you see any difference in the quality of the milk?

RAY PEAT: Oh sure, yeah. Men aren't nearly (chuckling) as good at lactating--

ANDREW MURRAY: Not so much fat maybe.

RAY PEAT: And it's a very extreme thing. Lots of men, when they came out of the WWII prison camps, when they started eating, they got enough energy to mobilize cortisol and some thyroid and such, they began lactating, because they had injured their tissues so much that they were very high in estrogen.

ANDREW MURRAY: Wow, I mean, it's well documented now and it's certainly not hidden that male breasts, or gynecomasty is a common phenomenon in males that are exposed to estrogen, and from the industry in England, the beer drinking, it's not uncommon for men that drink a lot of beer daily to grow basically breasts, and I mean even in this country, related to estrogen substances, whether it's the hops, the estrogen mimics in hops, or even environmental mimics in plastics, etc. that get into the environment that some more sensitive individuals are being exposed to.

RAY PEAT: Yeast can produce estradiol, and so they think that the yeast fermenting is a major source of the breast development in beer drinkers.

ANDREW MURRAY: Interesting. So, it may not necessarily be down to the humulone, lupulone or the other byproducts of the hop?

RAY PEAT: Yeah, they're probably not as harmful as the yeast-produced estrogen.

ANDREW MURRAY: Okay, you're listening to Ask Your Herb Doctor on KMUD Garberville, 91.1 FM. We're joined with Dr. Peat who's on the show basically questioning the endocrine system or what we understand about it and finding out some certain differences and contradictions that perhaps people understand the facts by until they hear differently. The number if you're in the area is 707-923-3911. If you're outside the area and would like to ask

Dr. Peat any questions from 7: 30 on, there's an 800 number which is 1800-KMUD-RAD, which is 1800-568-3723. So, let's move onto the next hormone in the hypothalamic section of this endocrine discussion, the corticotropic releasing hormone, how this stimulates adreno-corticotropic hormone from the anterior pituitary, and this acts on the adrenals to promote and secrete cortisol. Now, most people have probably heard of cortisol if they're at all health minded. Cortisol, cortisone, hydrocortisone. They're all kind of derivatives. Most of these derivatives here have at some point in time, and or are still, being used to control inflammation and I have known asthmatics and eczema patients and psoriatic patients that have been prescribed cortisol and corticosteroids to control that. The natural production of cortisol is inhibited by a negative feedback mechanism, so we're never normally naturally constantly and chronically exposed to cortisol. It obviously has some beneficial effect, although I understand your interpretation puts a far more negative view of cortisol, probably in relation to its chronic exposure, but what dangers do you see in the chronic use of hydrocortisone, either topically or aerosolized, and what would be a better approach to quell inflammation then of this type that you're aware of?

RAY PEAT: Within the first two or three hours of a big dose of cortisol, or the synthetic glucocorticoids, the thymus gland starts shrinking and the skin and muscles begin shrinking as the cortisol shifts the metabolism in the opposite direction of testosterone.

ANDREW MURRAY: Towards the estrogenic side?

RAY PEAT: Well, they activate the proteolytic enzymes that break down the proteins and inhibit the anabolic protein synthesizing mechanisms. The brain, heart, and lungs are very concentrated testosterone metabolizers and retainers. If you give someone radioactive testosterone, you see the emission from those organs, most of it from the heart and brain, the lungs are so full of air you don't see much radiation, but the testosterone is there protecting these vital organs, but when you give a big dose of cortisol you slump that protective effect of progesterone and testosterone, and the tissues that aren't very well protected very quickly shrink. Your skin becomes thinner, blood vessels weaken, you tend to get little bloody spots, Petechial hemorrhages, and bruise very easily. Lots of women have constantly bruised thighs and sometimes upper arms. If they're low in thyroid and progesterone then they compensate with increased cortisol which weakens their small blood vessels and they bruise easily. If that continues over the years, it leads to strokes and osteoporosis and the typical aging conditions.

ANDREW MURRAY: I've known people in England especially that, I don't know whether or not the doctors there were just more readily prescribing aerosolized inhalants, corticosteroid inhalants for asthma and or topical creams for eczema, but it was the only thing that was ever really done and I've known people that have been on these things for years and years, and I'm sure to their detriment. You're saying it's essentially switching off the protective, anti-excitotoxic mechanism and route by which inflammation typically, or estrogen-induced inflammation, is mediated.

RAY PEAT: Yeah, and asthma is one of the typical estrogen-induced inflammations. High estrogen women are very susceptible to asthma, especially during the night. And one of the effects of estrogen is to directly stimulate the adrenal glands to produce cortisol, so high estrogen leads to weak blood vessels and shrinking bones and aging skin and low immunity and such by the shrinking effect of cortisol on the thymus gland. And estrogen shifts the balance towards serotonin, away from dopamine, and this shift in the serotonin-dopamine ratio is one of the things that activates the prolactin system and it also, serotonin is one of the major activators of the corticotropic release hormone, CRH. So, estrogen activates the pituitary, the hypothalamus, the adrenal glands directly, to increase the tissue breakdown effect.

ANDREW MURRAY: Okay so, I caught on what you said about female asthmatics getting particularly worse at night and this, again, I guess this is time stress that worsens the inflammation?

RAY PEAT: Yeah, all of the stress hormones. - It's low blood sugar.

ANDREW MURRAY: Right, rise during the night.

RAY PEAT: Right, and again, in response, probably the low blood sugar because of fasting, or?

RAY PEAT: Yeah, and hypoglycemia or disturbed oxygen availability increase both prolactin and usually growth hormone. Stress induces, I think, all of the pituitary hormones except for luteinizing hormone, the one that produces testosterone and progesterone. So... When you activate all of the other parts of the pituitary, you're likely to become sterile by losing your progesterone and testosterone.

ANDREW MURRAY: I think from a male perspective it's, for those males that are listening, I know we do tend to get more female listeners that I think intuitively are more nurturing and, I don't know, empathic maybe. But, for the guys that are out there, I think testosterone, it's extremely important to reiterate not just the prostatic involvement with decreased testosterone, but to maximize your testosterone is the best thing that you can do as a guy because it is the counterpart to estrogen and it is the anti-excitotoxic route by which inflammation is quelled and the body's governed by a orderly system of growth and sugar metabolism, etc.

RAY PEAT: It's close enough in function to progesterone in protective tissues. They've experimented removing the ovaries from rats after they've been impregnated and then giving them testosterone during pregnancy. It is a progestin in that sense of being able to sustain pregnancy in the absence of ovaries.

ANDREW MURRAY: Well, I guess we do actually have a caller. So let's, I'll pick up this question I wanted to ask you about testosterone for the males that are listening just to help them see their way forward through any lack of muscle and muscle-building and how testosterone's really very beneficial for you and you can generate it yourself. You don't have to buy it, etc. etc. So, let's take this first caller. Caller, you're on the air, and where you from?

CALLER 1: Hi, I'm from the San Francisco bay area.

ANDREW MURRAY: Okay hi, what's your question?

CALLER 1: I'm wondering, can an imbalance of hormones influences someone's perception of his or her gender? I'm curious as I'm certain we're constantly exposed to environmental estrogens and I've also heard of instances like Caitlyn Jenner where Bruce Jenner knew from a very young age that he was the opposite gender. So, what's your take on that?

ANDREW MURRAY: Yeah, Dr. Peat?

RAY PEAT: When that happens during gestation or in the first few months after being born, the actual cell structure of the brain is still going on, and it's either masculinized or not by the presence of testosterone which is turned into estrogen, and estrogen in those stages of development is the masculinizing hormone. And so, a deficiency of progesterone early in life leaves the estrogen unopposed and tends to masculinize the brain, and so it can set up the feeling of, the gender is chemically activated rather than what the chromosomes were able to do.

ANDREW MURRAY: Yeah, the physical. Does that answer your question?

CALLER 1: That does, thank you.

ANDREW MURRAY: Yeah, you're welcome. Okay well, let's see here, we do have another caller. So, let's take this caller. Next caller, you're on the air. What's your question and where you from?

CALLER 2: Yes. Good evening.

ANDREW MURRAY: You don't sound like a (mumbles).

CALLER 2: I'm calling from Finland.

ANDREW MURRAY: (laughs) Okay, Finnish, thank you.

CALLER 2: I would have a question, I've been reading your wonderful generative energy book and basically it's prompted me to think about what I think they call now transhumanism. Nowadays we have basically the modern version of the six million dollar man. We have people with robotic hands. A friend of mine with Parkinson's disease has two chips implanted in his brain with remote control, and my question to Dr. Peat would be, do you believe that this transhumanism might fit into future evolutions of man? I'm referring to this theory about life trending towards maximum metabolism, maximum energy. I wonder if you have any thoughts about that?

RAY PEAT: I think the technology is so simplified compared to what actually is needed by the organism to maximize its metabolism and function and experience, that I don't think the technology is going to have a role in future development of health, longevity, or brain development.

ANDREW MURRAY: It's certainly not gonna be passed on to the next generation, so it's certainly a very temporal thing and I think from my perspective, the human body, and I think the psyche, plays a much bigger part in the protection and the development of the human organism, far more than perhaps people give real credit to for positive thinking, etc etc, self empowerment. Doing the right thing, in terms of everything that you propose, in terms of nutrition, and or some of the few supplements that you recommend, things like thyroid and progesterone and things that protect the anti-inflammatory side. I think you have a far better chance of living a genetically very healthy life and something that I think can be passed on to next generations. Certainly we hear about in-utero effects onto the fetus. I for one, I'm fairly interested about the transhumanism subject with, like the caller's mentioned, things like robotic replacements and or chips to secrete or prompt secretion of neuropeptides, etc etc into the brain or other areas, but it doesn't continue. It's a very temporal thing. I don't think it's something that can ever be transmitted but what can be transmitted is a mental state of mind that is based on positive thinking, creating that in harmony and, whether it's yoga or doing exercise and getting outside, and just appreciating everything that you have around you rather than looking at negative things which I do hear people calling about from time to time in terms of the help with negative emotions. It's actually one of the questions, funnily enough, later on for the show, but this is something--

CALLER 2: May I ask a follow up question?

ANDREW MURRAY: Go ahead, yeah.

CALLER 2: I was wondering about, because this is a topic that I haven't heard on the show yet but we're also in an increasingly hairless society. People want to shave more and more of their bodies more and more regularly. How stressful is frequent shaving to the body, in your opinion?

ANDREW MURRAY: It's interesting you say that. I'll just jump in there, Dr. Peat, before I let you answer, but I read the article just a couple of days ago, actually it was on the Drudge Report. It was that the increasing hairiness of females is becoming recognized in polls. I think they did a poll in 2004. I think 95% of females shaved. They did a recent poll here, I think it was down to 78, and they were saying that essentially there was more, au naturale was becoming more, becoming more normal. Whether or not you're talking about the hair on a male's head from a baldness perspective I don't know, caller, but Dr. Peat, what do you think about the--

RAY PEAT: I think the hair on the head actually has the function of preserving heat, helping to keep the brain warm. Wearing a wool hat will substitute somewhat for not having enough hair on the head. And the other hair, arm pits and pubic hair, I think that has the function of helping to distribute pheromones, somewhat--

ANDREW MURRAY: Like a moth's antenna.

RAY PEAT: The facial hair and arm hair probably has that pheromone distributing function. But, I think the body hair that is tending to appear more often in women is a sign of stress. It's probably related to that pheromone system, shifting to an exaggerated steroid production in skin.

ANDREW MURRAY: Okay, well thanks for your caller, caller.

CALLER 2: Thanks for the show.

ANDREW MURRAY: Yeah, you're welcome, thanks for calling in. For people that want to call in with any questions, if you're in the area, 923-3911, that's 707-923-3911, or if you're outside, somewhere in the states, or even in a different country, 1800-KMUD-RAD, 1800-568-3723. So Dr. Peat, just to carry on with testosterone a little bit. It's a bit of a divergent question, but in terms of men being able to maximize their testosterone production without thinking they have to go to a gym and get aerobic and pump huge amounts of weights to build muscle, what would you say would be a good program for a male who wanted to increase lean muscle mass in order to be exposed to more testosterone, 'cause it's the muscle itself that'll actually promote a testosterone surge in the body and, by its own mechanism, will directly relate back to testosterone itself.

RAY PEAT: Yeah, muscles' contraction activates the synthesis locally in the muscle of testosterone and decreases the cortisol activity. So, good physical work is probably the central thing to keeping your testosterone up. It shouldn't be episodic, intense, stressful work. That is known to lower your testosterone and increase cortisol. And at the same time, keeping your metabolic rate up so that you can do more intense activity without it being stressful. Having your liver very healthy is essential for keeping your testosterone up, because otherwise the episodes of falling blood sugar activate cortisol, estrogen, all of the other stress hormones.

ANDREW MURRAY: Okay, so stocking your liver with plenty of sugar, not being aerobic about your approach to exercise, and ideally having more of a kind of work approach that is a physical type of work, if you're possibly able, okay. So, (clears throat) excuse me, moving on to dopamine. I wanted to ask you a little bit. I know we've mentioned the discussion related to Parkinson's and Parkinsonisms. We said that this dopamine itself inhibits prolactin release and helps regulate emotional responses, and the reward and pleasure response is something I wanted to ask you about. This enables a person not only to see the rewards but to take action to move towards them, and lack of dopamine has been cited and implicated in the propensity to addiction. If you want to feel better, and mood enhancing drugs are a route to this, does this imply that many addicts have naturally low levels of dopamine and may develop Parkinson's type symptoms in future? And, would dopamine supplementation be useful to ween addicts, or prevent addictive behaviors from developing?

RAY PEAT: I think that, even in Parkinson's disease, I think the studies are moving towards thinking of a balance between serotonin and dopamine and the other symptoms--

ANDREW MURRAY: So, you're thinking that serotonin excess might exacerbate--

RAY PEAT: Yeah.

ANDREW MURRAY: Yeah.

RAY PEAT: They are somewhat antagonistic. For example, serotonin increases as the CRH, and prolactin, dopamine tends to inhibit them.

ANDREW MURRAY: So bad bowels, or bad bowel function, or poor elimination, would certainly speed that serotonin excess up.

RAY PEAT: Yes, nitric oxide, endotoxin, and serotonin all shift your body towards distress. And progesterone and its derivatives in the brain, allopregnanolone, for example, are important for keeping the balance in the right direction. Estrogen increases serotonin, and stress progesterone tends to reverse that and increase the balance towards dopamine.

ANDREW MURRAY: So, do you think, though, that this would be any reason or cause for Parkinson's down the road, though, perhaps if people have addictive natures if it is at all connected with lack of dopamine?

RAY PEAT: Well, I think you can correct it most safely with progesterone and testosterone or the precursor of both of those, pregnenolone, because when you try to push the dopamine system, you tend to increase oxidative damage and it's safe to work at the anti-stress level rather than pushing the end product of dopamine.

ANDREW MURRAY: Got it, so, improve muscle mass, plenty of sugars, and obviously pregnenolone, thyroid, all helpful and anti-inflammatory aspects.

RAY PEAT: Yeah, and keeping the toxic fats down and sugar stable.

ANDREW MURRAY: Okay. So, can I ask you about growth hormone? So, the growth hormone releasing hormone stimulates growth hormone release from the pituitary, again, from the anterior pituitary, and this has regulatory effects on protein, carbohydrate, and lipid metabolism as well as promoting slow wave sleep, often referred to as deep sleep. And I know people that perhaps have sleep issues where they're unable to get into that phase of deep sleep. I did read that the slow wave sleep was apparently, but I know this is not particularly true, because I know you think it's very much related to low blood glucose, but the slow wave sleep was implicated in nightmares and sleepwalking, especially when sleepwalking was joined to raiding the fridge at night to eat, and I found that quite a bizarre connection, but, I think it's well-known in popular culture, I remember an old advert back in 1970 for R White's Lemonade, and the advert was more or less this person was getting out of bed and sleepwalking downstairs to the fridge where he'd go open the fridge door and there'd be a bottle of R White's Lemonade there and he would sit there drinking it and his wife would come down saying, "What's going on?" But anyway, between the desires to eat, sleepwalk, and growth hormone, do you think the deep sleep that it relates to is in any way, do you think this is a real subject, or do you think this has been, again, mismanaged scientifically?

RAY PEAT: No, I think deep sleep is important as a restorative part of your brain function, and I think a lot of people would be happier and healthier if they would eat during the night. People who resist eating near bedtime or during the night often have more stress, more hypoglycemic insomnia, and most people can get back to sleep if they have, could be orange juice, or lemonade, or a milkshake or ice cream, or--

ANDREW MURRAY: It's almost a cultural barrier where there's this feeling that if you eat close to bedtime you're just gonna put it on as fat. I think I've certainly heard that doctrine that excess carbohydrates are stored as fat which, I don't know that it's completely inaccurate but the nighttime stress that is achieved by lowering your blood glucose is probably offset by the very fact that you're gonna consume some glucose before you sleep.

RAY PEAT: Yeah, it's very important to restore your glycogen levels during sleep. I think that's one of the main purposes of sleep, is to get the glycogen back into your brain cells and heart cells, and other tissues, so that you can expend it to resist stress during the day time.

ANDREW MURRAY: Okay, well let's move on to a few questions that I have that I know people have written in that have wanted to get your take on this. I had two questions from one listener. One of the questions goes, did Jimmy Carter's cancer cure have anything to do with receptors? Isn't the entire cell a receptor, question mark.

RAY PEAT: I think he was having standard chemotherapy for a while and then brain radiation, and then he got this new antibody that is specific for allowing cells to undergo the normal apoptosis. So... Statistically, it doesn't look like it was a terribly impressive cure, because the number of people studied was not very big and the percentage who responded well, I think it was 24% had a temporary regression of the tumors, and that happened in a lot of the people who had only the preceding brain radiation.

ANDREW MURRAY: Okay, alright. Their other question, I wonder that it might be a little bit self-explanatory perhaps, but it says, since gums like carrageenan and xantham gum are toxic, does the same apply to gums like frankincense and myrrh?

RAY PEAT: The carrageenan and xantham are basically polysaccharides. The carrageenan is a sulfated polysaccharide and I think all of the sulfated polysaccharides have (mumbles) heparin. I think all of those are toxic and dangerous and the xantham gums and gum arabic, and lots of the plant gums, are not digestible, but they can support bacterial growth in the intestine. Where the carrageenan is specifically pro-inflammatory and very dangerous, the other gums are simply nuisances that tend to increase bacterial growth and gas production and such. The frankincense and myrrh contain lots of anti-inflammatory substances, probably anti-cancer effects, some steroid-like molecules not so different from testosterone and progesterone. They seem to have an anti-inflammatory, anti-proliferation effect on cancer cells.

ANDREW MURRAY: I wasn't aware of myrrh being used internally but I've known frankincense for a long time, especially by the Bedouins that would chew frankincense straight of the tree in the pearls that it comes formed in when it dries to freshen their breath and as a kind of bacteria static for their teeth and their mouth.

RAY PEAT: I've heard of people eating the crude gum ground up just by the spoonful.

ANDREW MURRAY: (chuckling) Okay--

RAY PEAT: On the issue of receptors, there are actual proteins that are called receptor proteins but my position is that, since the condition of the cells determines what a particular substance binding to that receptor is going to do to the cell, it isn't as meaningful as some people think to activate a receptor, because it can have opposite effects depending on the history of the cell and the present condition of other cells.

ANDREW MURRAY: While we're talking about cells, just quickly, what's your view on stem cell technology? Do you think it's a real way forward to turn around degenerative processes? What do you think about stem cells?

RAY PEAT: Yeah, I think we're full of stem cells and (chuckling) what we have to do is activate them intelligently.

ANDREW MURRAY: Yeah, do you think the research is going in the right direction? You probably know more about what is actually being conducted in some of these experiments, and see if it's actually reasonably positivable or to bring about something positive.

RAY PEAT: Yeah, finding out exactly what the kind of stress signal is that activates them. It's already known that many types of stress will activate the maturing of stem cells and that things like progesterone and testosterone, once they have been activated, will keep them going in the right direction, so that they replace tissues rather than replacing cancer. When they kill cancer by radiation or chemotherapy, or surgery, the cancer tends to come back even though they removed the tumor completely because the place where the cancer was has been injured and it calls out to the body for stem cells to repair the damage, and being damaged itself as a framework, it misdirects the stem cells so they develop into cancer.

ANDREW MURRAY: We have a caller that's just called in so let's take this next caller. Caller, where you from and what's your question?

CALLER 3: Hi. My name's Derek, I'm here in Denver, Colorado. Can you hear me okay?

ANDREW MURRAY: Yeah, sounds great, what's your question, Derek?

CALLER 3: Well, first off, I just discovered the show not too long ago and it's just fantastic. I really appreciate you taking your time to do this for the public. So... I've been into nutrition research for the last, I don't know, last five years or so, and looking into, I've had a lot of food intolerances, and looking into, like, gut permeability. And I'm curious, Dr. Peat, your take on, 'cause a lot of these protocols involve avoiding otherwise really nutrient-dense foods, eggs, dairy, etc. So, I'm curious, I've looked into controlling endotoxin through various polyphenols. I know you talk about the carrot salad and bamboo shoots. But, is there any other compounds you like to incorporate to heal or strengthen the lining of the intestines? I know gelatine can be beneficial.

RAY PEAT: The nutrients that are most important are magnesium and vitamin A, just for the actual replacement and repair of cells, but the whole range of nutrients, protein, zinc, vitamin D, anti-inflammatory, things like vitamin E and vitamin K, everything is really essential ultimately for protecting the intestines. So, having liver and eggs and milk and orange juice, for example, can often get the repair going. I think the reason eggs have a bad reputation is that they're extremely concentrated protein and if a person eats an egg or two without carbohydrates, their blood sugar is going to fall for sure, especially if their liver doesn't have good glycogen stores. The egg will drop their blood sugar, that will activate mast cells, and you'll have allergic reactions.

CALLER 3: Ah, that is fascinating.

RAY PEAT: Any pure protein without the carbohydrate, you're going to increase inflammation, and sugar and progesterone and asprin are things that will protect you from those surges of histamine and serotonin, etc.

CALLER 3: And, does the histamine get produced because you don't have enough glycogen due to a cortisol spike then?

RAY PEAT: Well, low thyroid ultimately is the most common reason for not having enough glycogen stored, and the cortisol weakens the tissue so that even though it helps get your blood sugar up and momentarily protects the glycogen, in the long run it's adding to the problem of unstable blood sugar. And any time your blood sugar falls, the mast cells are likely to degranulate, and that's influenced by a lack of testosterone and progesterone, or an excess of estrogen.

CALLER 3: And, am I correct in understanding that thyroid is oftentimes, or lack of thyroid hormone is oftentimes a root cause of small bowel overgrowth, or SIBO, which can--

RAY PEAT: Yeah, because's your...

CALLER 3: Kind of be a root cause of leaky gut.

RAY PEAT: Your digestion slows down when your metabolic rate slows down from hypothyroidism, and so your stomach becomes sluggish, doesn't secrete much and doesn't move fast enough. People might have transit time, they might eat a carrot today, and it might not come out for four or five days. That's what happens with hypothyroidism, and speeding up your digestion and secretions, it should be so active, streaming fluid from your stomach and pancreas and liver should wash your whole small intestine clean so that no bacteria can thrive in it.

CALLER 3: And Dr. Peat, real quick, I don't wanna hold you up too long. Is there a, a good quality nutrition-based textbook that you find favorable, that kind of gets into good mechanisms with nutrition and hormones and their relation?

RAY PEAT: Not that I know of.

CALLER 3: (laughs) That's what's tricky. I mean, I know there's some great online databases for some good research that's put out there, but I just didn't know if you had a recommendation there. I really appreciate your time.

RAY PEAT: Years ago, I've seen some really good monographs on particular topics, like how the intestine works, how the digestive glands work, and so on, but I don't know of one that has put everything together.

CALLER 3: Sure, sure, sure. Well, I guess that's part of the journey. Thank you so much, I appreciate your time.

ANDREW MURRAY: Yeah, you're welcome. If you want to email me, my email address is andrew@WesternBotanicalMedicine.com We've produced a pretty comprehensive three or four page breakdown of those things that Dr. Peat definitely advocates, and those things he definitely doesn't advocate. So, that's certainly been very useful in guiding a lot of our clients to a better place. Dr. Peat, thank you so much for joining us again.

RAY PEAT: Okay, thank you.

ANDREW MURRAY: For those people who perhaps, like the last caller, have never really listened to Dr. Peat but just discovered him recently, he can be found on the internet at www.RayPeat.com He has lots of archived and referenced material. So, most if not all of the articles that he writes are fully referenced, and they range in broad terms, from thyroid, to sugar, to progesterone, to diabetes. It covers a wide range of situations and gives you the scientific rationale behind why he's advocating what he's advocating. So, it's not just flippant, off the top of his head. It's based on a lot of research and based on a lot of previous good science, which unfortunately is becoming fairly bad science today. And if we get time next month, we'll get into the newsletter that he's produced. It's titled Language and Criticism of Science. We've done quite a few exposes of, whether it's Codex Alimentarius after the second world war and the development of the global corporate structure which would squat on our necks, to this discourse that Dr. Peat's outlined in his newsletter mentioning people, organizations such as the CIA, and the CCF, and the Rockefeller and Ford Foundations, all basically being in on it. We'll get into that next month. But, for those people that wanna find out more about him, RayPeat.com. We can always be reached, Monday through Friday, toll free number is 1888-WBN-HERB, or I can be emailed, andrew, or sarah@WesternBotanicalMedicine.com So, next month, we hope to be here. I don't have any plans, but I may or may not end up getting off to England. But, based on the fact that I'll be here, it's gonna be already the solstice. So, it's already gonna be upon us. So, this will be the last month of increasing day length. So, between here and the next couple of months, (serene flute music) you've got a chance to get exposed to lots of sunshine, get that anti-inflammatory red light, get your vitamin D going. Make sure you're drinking plenty of milk, getting plenty of sugar, fruit juices at night time, keep your stress hormones down, look at your temperature and pulse to see how your thyroid's doing, and address it. It's certainly a very simple way of putting things right. So, between your thyroid and anti-inflammatory hormones, and get your testosterone up, guys, certainly put you in a better place, alright? And it's all pretty much free of charge. Okay, so thanks for joining us, and we'll speak to you next month.