Hacking Your pH, LED Lighting & Smart Drugs Part 2

Video | Dave Asprey

00:00:00 > [Music] everyone Dave Asprey bulletproof executive radio you're listening to a special episode if you caught the last one in fact if you haven't caught the episode before this one you need to go back and listen to it because this is part two of my epic interview with Steve folks who doesn't like it when I call him a biohacking badass even though that's what he is so Steve folks is the head of the cognitive enhancement Research Institute he's an adviser to the Silicon Valley Health Institute the anti-aging research group that I'm chairman of in Palo Alto we meet every month and you can actually meet him there svh Icom and he also runs project well-being calm where he blogs Steve's has a background with nutritional supplementation he's a biochemist and he and his work literally saved my career in my mid-20s my brain started shutting off it was his writing about smart drugs and mitochondria that helped me get

00:01:02 > myself to the point where my brain worked and I could use it to hack the rest of my body so I am i oh steve a debt of gratitude you heard all that on the last episode already so I'm cutting it short his accomplishments so just listen to this go back and hear the first one if you haven't already done it if not Steve is back we're going to talk smart drugs we're going to talk more about lighting and we're generally going to have a good time so Steve kick it off let's talk lighting I think lighting is one of those departures from a real life world that we we've lost our connection to light we've lost our connection to magnetism we've lost our connection to food and every time we depart more and more from our roots or biochemical and biological roots we end up getting into problems and so lighting is a really great thing to do because it's relatively easy to do and if you really want to be you know geekish about it you can get into very

00:02:05 > very nice aspects of LED technologies and stuff like that so if you like toys you can certainly do with light let's talk toys $30 Costco I have a strip of LED lights here above my desk and I'm holding this up if you're not if you're driving you don't see this but if you're here you can choose brightness and intensity and you can choose color spectrums so right now you see I have kind of a red issue I've got red lights on but if I wanted to be like purple so you have to aim it at the lights there now I'm kind of purple you see the how it all changes so at the touch of a button you can go you know more of a yellow spectrum or just bright white if that's you know what your mood it's relatively dim right now so it's well known that if you want to advance I would say it's well known to me and some biohackers but to people listening to this it may not be well known so let me rephrase that some people know that you can say use a blue light in the morning which will

00:03:06 > shift you're making more of a morning person and if you're traveling for jetlag and all you can get some benefits from that and if you listen to most of my podcasts I've probably mentioned something in a lot of them about amber light at night cut down your blue spectrum at night so you can go to sleep but these new technologies that are dirt-cheap allow you to do stuff with colors that really wasn't achievable five years ago the intensity and brightness of the leds is there so Steve as a biohacker and master of all sorts of strange knowledge what colors when are optimal for people want to kick more ass well if you're if you're in it in harmony with your day and your biorhythms are in phase with the light dark cycle you want to have red light in the morning it needs to shift towards blue in the middle of the day and for most of the day blue dominance during the middle of the day and then it phases back down into red again as you prepare for sleep at sunset and this is the

00:04:07 > natural cycle now if you're out of phase with the day you're a night owl or you're a morning lark then you probably want to push those elements to into to kind of nudge yourself back into alignment with the day so for example if you wake up poorly your night album you wake up poorly you really want to do red light first thing when you wake up you know set up some red lights above your bed you know kick off your covers turn on the red lights and and you know bake your body in red and infrared photons and that will turn on your mitochondria it'll improve your circulation and that surge of energy that you'll get from that red light is the same thing that you would get by for example eating bulletproof coffee or taking some coconut oil or some MCT oil or doing some exercise and that you know creates an acidic momentum that moves you into the day and the earlier you do that the more you'll tend

00:05:08 > to adjust your cycle into the harmony with the normal daylight cycles so why does the Phillips and the Phillips go light why do they put a blue light in the morning I always thought that was a bit odd but what's what's the right isn't a problem it's just it has to be red and so you can no idea blue like an umbrella if they had at the same time as long as the red photons are there right and they aren't in those lights at nighttime the blue messes with your melatonin in the morning you don't care if your melatonin gets suppressed you actually kind of want it to be suppressed yeah so you know the blue light in the morning is fine but you have to have the red light so if you do fluorescence in the morning it's not going to help you it's going to damage you yeah fluorescent lights are just bad all the time as far as I can tell yeah so it's kind of funny and mounted above my bed I have a marijuana grow light an LED grow panel from Amazon which is all red LEDs it's a really bright one and I use

00:06:09 > that actually I use it at night sometimes if I want to read and I use it in the mornings and I do find though that after I get out of bed that turning on bright halogen lights which have white a lot of white and blue seems to help but getting a dose of the red is is a good thing yeah now I didn't you're doing it because of its effect on my tocando mitochondria and so okay so Sam affects your respiration okay and and that happens through something called cytochrome a is B which is part of the mitochondrial lining if memory serves is the electron transport chain cytochromes absorb infrared and red photons and because the amount of energy that you get out of the oxygen hydrogen you know redox potential there's a certain amount of voltage there and because we get you know let's say 70% of that energy out there's only 30% of the energy that's driving the cycle which means that if it

00:07:11 > makes a huge difference as to the dynamics of putting small infrared photons in they don't have much energy but putting them into the cycle to help move the electrons down the electron transport chain gives you more ATP make sure mitochondria more efficient and that's part of the way in which mitochondria normally operate they're normally bathed in a in a light field where all these photons coming in from the Sun from being out in the world and that's Sora mitochondria are optimized for being in that kind of environment yes yeah and we don't have that anymore and a lot of people are weak in that area so this is one way to encourage it is to say okay while I'm embedded in the morning before I get out of bed I'm a captive audience I can read a newspaper eat a book something while I'm laying there with the with the red lights on me or you can set it up in your shower so that you doesn't actually take any extra time you just flip on the red light when

00:08:12 > you're in the shower you do the shower thing you have the red light from the front in the back so you're getting you know and hopefully you're not enclosed in the shower so your skin exposed to drink last night no it may be an issue if you sleep with you know flannel then you the issue of taking off you know your clothes so that you get direct light on your skin um it really is important to do that and and the penetration ability of red light is um inches and the penetration ability of infrared light is many inches and there are medical lasers that can actually treat your spine through your stomach I I have one yeah a medical laser that does that with infrared and actually Ruby two different heads on it and I'd have had that for almost 15 years now and it's just shocking what you can do with light like that yeah how long do you do this for Steve in the morning all right a five minutes got it and I noticed a boost at night I sleep better when I have the red lights I believe it's because in fact I'll tell

00:09:13 > you I know for sure that when my mitochondria are working better I sleep better because well it's also the case that darkness produces an adaptive response and so if you are not having red light your dark adaptation mechanism kicks in earlier and that involves on a major level cortisol which is lowest at dusk and then rises during the night to peak at dawn and so that's a dark adaptation mechanism and so if you do a graceful of photo fading from you know blue light to red light before you go to bed at night that's when your cortisol starts rising and then if you expose yourself to red light in the morning that's when your cortisol starts dropping so you're in a sense bracketing your cortisol so that it doesn't bleed into other parts of your life when it would be kind of a cumulative deleterious effect that is cool and I didn't actually realize that I was bracketing cortisol that way I haven't

00:10:14 > looked so much at red lights and Corozal I've looked at not having blue light at night in melatonin in reducing cortisol the other benefit of red light and the reason I started with my grow light is that red light causes collagen synthesis which is particularly cool so if you want to have healthier skin and you and I both are huge collagen fans but I don't ask you about that in a minute making more collagen when you have enough vitamin C in you have enough collagen peptide in the body it's just a good thing so I used to mount the grill light actually by my feet in my office it's you know a panel that's 1 foot by 1 foot but it must have I don't know 75 LEDs or something on it and I did move it up to Y sleep because I thought oh this would be kind of cool have you ever slept with red lights on all night no and why would you not want to do that I I don't know why but it's just not something that would happen in nature so that would be my inclination is to say it's a departure from major and since I don't have any evidence that this is a good thing I'd be inclined not to do it but I mean I'm looking at that antiquated like I think it's a museum piece of a computer behind

00:11:16 > you there Steve and that's sub departure from nature and you do that I mean where's your other line but I do red lights when I work on a computer at night yeah okay the same same here that I do and for people who are the idea is that red light is an antidote for blue light yeah so you know you just use it therapeutically because you know I'm just not willing to give up a computer not me either I mean let you have to have standards here all right I'm gonna grab another light to show people give me like five seconds here well dad scientist in his workshop I just dropped my one of my lights but this is the one I wanted to to show this is a 12 dollar light from Amazon it's a color tunable LED floodlight and it's twelve box comes with the same remote control you can pick the color and everything else so I did a really good job there with the electrical tape of putting the backward

00:12:18 > on there I mean I tech yeah super high end but it's kind of cool so you're talking 12 bucks for a floodlight or around $29 for a strip light that will run all the way across your desk back and forth and even under your desk if you want so it's become frightening ly cheap and it's a remote control you press a button and you get your red light you want blue light or you want purple because you're feeling special it doesn't matter but this is something that I believe it's going to have far-reaching effects on people's biology and it just now became available before that you had to put color filters on your lights and they would smell and it was just a pain so this is an area biohacking that deserves more attention and of course you're on top of it more than I am Steve which is yeah how do you do that I also encourage the really really really low tech side of it as well which is an ordinary incandescent heat lamp what incandescent lights that's right incandescent lights 250 watts see if they have no mercury they don't have a curly thing in them they're not made in China come on like we're sorta moving

00:13:20 > spear yeah the stuff your grandmother had in her bathroom to stay well red light yes those work perfectly fine well there is a problem and there's a limit how much red and infrared you can get into you because of heating effects you don't want to ever heat the skin up enough that you start sweating or that you feel uncomfortable that just generates heat shock proteins and other you know inflammatory you know mediators so the idea is you want the bulb to be far enough away that when you flip all your covers off and you're naked in the morning for example that you're warm okay about that now here's a here's a question for you though I take this red light this really bright floodlight I think it's a 30 watt LED which is substantially powered and I put it up against my abdomen I'm I'm actually increasing mitochondrial function in the gut specifically and that that thing is going to penetrate essentially all the way through you yeah and I'll do that for five or ten minutes and you can feel a difference in how

00:14:22 > parts of your body work I've put it over sore muscles and things like that and there are definitely people out there doing research with these on how the levels of light affect mitochondrial function do you think it's potentially advisable for you know say an athlete someone like that to maybe use a red light in a more concentrated way on the body or the make sure that it's it's a wide open realm for study and it makes sense to me that anything that makes mitochondria more efficient can have profound effects so sorry I'm getting like bright lights in my eyes reflecting off the pond outside there we go now now I can see you so normally I don't bounce around on video quite as much but a lot of people are watching or listening this in their cars so they can't tell ya you're just being a bad influence yeah exactly so the other light that I dropped I'll show you this one Steve see what you think about it yeah you're getting your your stretching in this is

00:15:24 > like my bio soccer you know around the head thing you know you get your proprioception where you don't have to look at your hand when you stick it in your ear and and I've got my left-right balance going on so I'm tending the headphones this is another LED light but this one is a camera illuminator 850 nanometer light and this one reaches very far into the body and really turns on mitochondria to the point that you could probably harm yourself greatly with it but if you do it for a short period of time it causes hormetic improvements in mitochondria it's like weightlifting free mitochondria that so that would be highly adapted to let's say that kind of therapy in a medical office where they would want you in and out in seven minutes yeah in fact I think seven minutes is too much I've done five minutes with this light and it knocks me out for a whole day like I was on okay two minutes for them to come in three and two minutes for the exit and this I haven't talked so much about this except in a couple south-by-southwest presentations but for actually for this

00:16:26 > one for 15 years I've had a farm for red stimulator that I've used on my brain at various times with huge effects and now it's becoming more mainstream but this is one of those one of those types of hacks that people often times it sounds too good to be true like really he's trying to with a high-tech flashlight on my head but you just went into the mechanisms which is awesome I didn't even know we were going to talk about that today but it figures there's no there's another benefit that we should also mention that is that the sinuses are one of the first places that your your mucus membranes get contact with allergens and infectious agents and you can you can shine red light up into your sinuses to augment immune system defense at that in that level all right or not now I have to set my headphones no not again just for one second all right Steve I'm back and I've got my nasal light you have one of these don't you yeah the Rudolph the red-nosed announcer

00:17:28 > you see things they're actually designed to put in your nose mm-hmm so yeah I've been playing around that as well is this it's good at parties - so just clips right under your nose so yeah this is why you should get the youtube or the iTunes video version but you stick it in your nose and I mean it is so sexy like the women part is if they just go for it right but it will I got him so when you put a light in your nose like that you're doing this for antigens I always did it cuz I'm illuminating the bottom half of the brain and I'm looking for mitochondria activity in the sinuses side and by way of background I had sinus infections like every month for 15 years before I fixed all this so I had the same problem you did okay so what's the mechanism of action of a red light in the sinuses oh I think you're waking up your mitochondria and sinuses and in doing improving antigen presentation mechanisms and immune system responses and white blood cells invading the mucous layer I mean all kinds of things

00:18:30 > Hey okay now we both sound like circus freaks at this point but I'm okay with that because the benefits of this kind of stuff are there they're real and this is stuff that medicine is largely ignored there's you know some cold laser applications some physical therapists and chiropractors are doing stuff acupuncture points but I mean come on this is dirt cheap you can't sell it with a prescription that you have to refill every month it's not good for business at all but it's good for us so I'm I'm particularly intrigued by this kind of stuff and it sounds like you are - absolutely we should have scheduled a whole whole session on this we could have both shine strange lights up each other's nose that's enough lighting yes all right let's switch gears and let's talk about another subject where you are the man this would be smart drugs and nutrients - you know you're the author of or a co-author of probably I would say the most influential book out there on smart drugs there's lots of good

00:19:31 > publications but this is one of the seminal works for for laypeople to understand what they are and how they work even though it's it's been out for a while but it's still a solid work so no it's an oldie by now it is so let's talk about one that I know that you are a giant fan of and that is piracetam it's one of my two favorite smart drugs of choice and I'm loaded up right now talking to you with it I really like it for a variety of reasons and one is that it helps me with my verbal skills and editing skills and speaking skills the whole language thing is something that my brain isn't optimized for I got a very lateralized brain where your left brain and right brain are doing different things which gives me wonderful spatial skills but really hurts me in the area of verbal skills and presa time allows me to kind of bring that level up to to a level of sufficiency where I'm very happy with it

00:20:33 > and there's another you know what I call a feminine trait of being multitasking and Preston gives me that so did you just say Preston was feminizing Steve feminine rather than feminizing and and I guess I'd like to get in touch with my feminine side on behalf of our of our approximately 40 something percent female audience I would say multitasking is a skill that men aspire to this true or that they just lust after yeah there you go and it's a skill that I kind of suck at although I'm better than I was and like you I use another racetam aniracetam is my favorite the Rolling Stone editor had the same effect I just loved aniracetam for me it's a memory IO thing I drop words less on aniracetam that I do on piracetam but I'm right now on aniracetam stacked with phenyl piracetam and I take those insult app and other stuff on a very regular basis because life is better when your brain

00:21:34 > can do both things right it's true but but you do wacky stuff with piracetam like you just use it for my Macondo function for I think thyroid so let's go deeper on for a stem because you're like the master of piracetam I don't know anyone who knows more about it than you like literally and all the people I've ever met you're the most knowledgeable Prowse chem hacker well I've discovered if you know one effect that is just fabulous for me that isn't in literature in the slightest and then I use press at am to become a to switch from a night owl to a morning person okay you just got everyone's attention right now like there's 50,000 people slam their brakes on when you said that how do we use I have no idea whether or not this would work for you 80% of people are only you know 8% of people but it works for me consistently every time right now in every Amazon seller of piracetam just ran out of stock okay so but so what I do is any time I notice that I start to drift and I start to stay up late the next morning I take a rounded tbsp oppressor Tam

00:22:37 > which is probably 10 grams or something like that the normal dose is about 800 to 1600 milligrams so you're taking about five to ten times the normal dose yeah maybe four times the total daily dose and I take it all in the morning none of it and the rest of the day so I you know I I load myself up in that morning I just you know slam it down it tends like rise if you take a tablespoon of water it's one of the most horrible tasting supplements out there well I dilute it in 8 ounces of water okay so you chug it I got it know if I did it in two ounces of water it would be horrible but listen I've spoon raw B complex vitamins element out and with it I taste buds are different than anybody else's on the planet at this point they've experienced more raw nastiness so process time is mild by compare in vitamins alright so I slam it down and that night I go to sleep at a reasonable hour the next morning I wake up at dawn with no alarm clock so you do it in the

00:23:39 > morning when you wake up and you don't want to stay up late and when you go to so you go to sleep earlier because you're on pasta time I actually go to sleep oh and then you wake up the next morning and you're done how many hours can you shift your schedule in one day can I use this for jetlag well it if I'm if I stay up til 2:00 or 3:00 in the morning the next day I'm I'm the the following day after that I'm up at dawn so it just automatically sensitizes me and it's all it I mean I don't know I haven't done more than three or four hours adjustment with this just because I don't travel I don't have any experience of of adding the jetlag ok synchrony to just being a night owl so so my next trip to the East Coast I think I have one coming up within the next 30 days for sure I have two other trips before then I'm I'll try huge amount of piracetam in the morning yeah it shot the figure I guess in the morning for where I'm going to be here's the way to do it alright let's see if this works this this could be a could be a cool thing I remember you've talked until May good podcast in a future event

00:24:40 > a good deal all right Wow all right that's exciting what are the other things per astmd people don't know about um it's a good remedy for altitude sickness um anybody who gets a lightheaded or you know sleepy on airplanes they crash into trees while they're skiing press stems very very helpful for that I used it once on a trip to central Utah when I was at like 8000 feet and normally at that altitude I'd be lightheaded and I was doing a Down syndrome conference so I had to be very sharp so I was doing loading up on press at him and not only was I absolutely clear so even on the flight I was you know sharpens in preparing but when I got there I felt so sharp that I took a three-wheeler up into the mountains about a thousand feet and followed a flock of turkeys wild turkeys up into the hills where you know I was going over all kinds of great and stuff and if you know anything about three wheelers they're very unstable you know

00:25:43 > they're just you know notorious and I had it under control the whole time is my first time on a three wheeler well maybe since I was like four or five years old or something every wheel didn't count but and it was it was great because I could you know I was totally in control I didn't get fuzzy-headed I didn't crash into anything it was sharp the whole time and since then I've I put out the message about this and other people have gone up and you know they live at sea level and they go up and they ski at 10,000 feet and they say yeah we did four runs today and then I came back and I partied all night now I you've it makes sense because piracetam increases oxygen levels in the brain without changing circulation and I have the stack that I use for high-altitude mountaineering and a bunch of mitochondrial enhancers because your mitochondria suck up there and you know you want some more carbs because you burn carbs better but funny ketones help so I have you know the whole brain you don't go out out of ketosis yeah exactly so you know I I think probably resistant starch might be good that you can stuff anyway but I always

00:26:44 > take an arrest Oh impressive damn and I remember in Tibet you know I was up for long periods of time you know 16,000 plus feet and sleeping above that altitude and a lot of people had to go down you know even on Diamox there they were getting altitude sickness and literally I was like I was hungry which never happens at high altitude I just felt amazing yeah and I never actually thought whether at that time the press end it's just like part of what I do was in fact in fact I was on piracetam back then I switched and harassed them because the memory IO effect for me is much better but they're similar drugs fat soluble and different you know half-lives in the blood but they are related so interesting Steve I'm so glad you said that so when you're on airplanes it totally makes sense to be on a racetam when you're on a surgical table it makes sense to be on a I'm not saying on an arrest and I'm staying on a rasa to dress the things the racetam family includes an arrest a moxtra a stamp ram or a stand phenol browse stem press and blah blah blah go to the internet search racetam you'll find them why do you stick with the old one perhaps damn the first one instead of some of these newfangled fancy ones like

00:27:45 > phenol that well I'm one I'm satisfied with result to the quality of the research that's been done it's it's so there's way more research on Prestone than any of the other rasa tomes no question about it and three there's a dishonesty factor in the research that happens with any me to drug that comes along yeah so when a first drug comes out it sets the stage and then all these me to drugs come in and drug companies have a have the power to withhold evidence and not report it so what you tend to see is this filtering of negative findings and a promotion of positive findings which makes me distrust the the balance of the emerging scientific literature for those kinds of drugs and the other reason is just that you know I've been busy with other things and because I'm so happy with piracetam I really haven't had that much

00:28:46 > incentive to try to hack it to a new level that's a wonderful answer you know that this pursuit of perfection you get a lot less return when you just nailed most of it I'm I'm kind of like that's a bulletproof diet like the new version like you know I moved blueberries over a little bit because of BDNF and okay it's pretty small tweaks at this point but it's mostly there and I think you're right like for me I read some studies about aniracetam that also talked about anti-anxiety effects like you know I think I'm good with that and when I ran my little experiment but either one anyone who's listening to this if you've never tried taking one of the rasa tabs they have anti-aging benefits they have cognitive enhancing benefits if you get in some sort of weird I'm drowning or I have lack of oxygen to the brain you won't get brain damage like I consider these to be anti-aging drugs as much as smart drugs do you agree with that yeah and and also anti trauma drugs so you know one of the things that I recommend for anybody who does a lot of traveling in

00:29:47 > automobiles is to have some DMSO diluted DMSO in their glove compartment so that if there's a trauma and they've damaged their spine damaged their back they can just take that bottle up and drink it and they protect their spine from paralysis of a DMSO or dema so with piracetam in it no just DMSO okay so this is just one of those things that you can do you know guy taking DMSO in advance is not good because it gives you bad breath you know it's like garlic wimp you know yeah it's very very you know unpleasant socially but if the the choice is having bad breath are being paralyzed it's very obvious that you don't use you would take the bad breath so you know you just want to have it on-site in that kind of a trauma situation and if you come across an accident where somebody else is injured you might be able to give it to them and prevent them from being paralyzed so you know it's one of those emergency things that is very useful to have around and it's one of the things

00:30:48 > that no hospital does that no ambulance carries all right so this is one I'm not familiar with that I'm familiar DMSO have used it on and off for years and MSM but what's the dilution and the dosage that you recommend for this because honestly I'll put a bottle down my car no no question about that typically about 1% so you want 1% DMSO and in what volume of water well you can you can it could be a quart but you know you're going to have a hard time fitting that into your glove compartment but you know a cup of water with 1% DMSO ok so you drink one cup of water that's 1% DMSO because I'm just imagining I don't even know about oral and take-up DMSO how much you're supposed to take I always use it topically so right and that's the typical way it's been studied is to put DMSO on the surface of the spine in the vicinity of the injury to prevent the damage but you don't have that luxury if you're in an automobile accident you're pinned under a car or you're you have clothes on cool off your clothes you get arrested so what you do is you drink it

00:31:50 > and it goes to your spine through your bloodstream so that's just an plus any tissue of your body gets equally treated if you drink it Wow all right I'm going to add that to my arsenal of cool bio hacking tools I do know that if I get any sort of spinal injury or any sort of situation like that I'm happy I'm already on aniracetam I would want to take more piracetam and I'd want to be sitting in the hyperbaric oxygen chamber really quickly probably with red lights shining on me but you've got to go and multiple modalities all of them low-tech but when you add it all up it's amazing and if you look at that what of those is patentable well the combination of anything that's is is potentially patentable but it's a use patent so it's worthless exactly by the way use patents cost about $10,000 if you go with a real legal firm how do I know but then you have to defend the patent and prosecute the patent and that's infinitely expensive exactly so this is one of those things where the reason you don't hear about this much other than from

00:32:51 > some bio hackers is that there isn't the profit motive and one of the reasons that I started the bio hacking thing and talking about it is that there's so much of this out there and if enough people do it and they get knowledge from guys like you and guys like me then suddenly it doesn't really matter if there's a company backing it up because these things work so obviously when you can feel the piracetam the next day well then there you go and there's other things like silh tap which I started carrying on the site in a long term chemical potentiation have you played with that stuff I haven't okay cool so we won't talk too much about that all right tell me about your collagen tryptophan cocktail because this isn't exactly smart drug but it's a brain affecting thing why do you do that well they the collagen I mean you know most humans can benefit from collagen because you know it's kind of a weak system in human than the human species yeah we don't make vitamin C so our collagen maintenance and production is compromised and just for people

00:33:52 > listening collagen the major connective tissue in the body I don't mean plump lips and eyebrows or anything like that versus this is what makes us different from jellyfish exactly you know so you're going to take your arm and you're going to smack it you know it's the collagen that prevents you from damaging the tissues and it's what would the quality of the collagen prevents you from bruising okay so you have weak collagen your ease of bruising so anybody who notices that they have random bruises appearing on their body and they can't remember how they happened you think collagen vitamin C that whole family of things um but what I found was that collagen had a predigested collagen when you break the collagen down into absorbable pieces this is basically upgraded collagen as the stuff I make right now right and when you when you do that all of a sudden the collagen does something that is very rare and that is it soluble Isis crypt of him and you know tryptophan

00:34:53 > normally a gram will dissolve in like you know thirty gallons of water or something like that so it's extremely non-soluble you take a capsule trip then put it into a glass of water you can stir it for weeks and it'll just float on the top it'll never dissolve and so you put a teaspoon of the collagen protein in the tryptophan dissolves and not only that but you can dissolve four grams of tryptophan in one glass of water Wow and when you dissolve it when you take that collagen with tryptophan you're going to go to sleep well it depends on how much you take but yes or you can bring somebody down from depression and they're suicidal you can bring bring them down if somebody is anxious and nervous you can calm them down their tryptophan has all kinds of benefits like that but because the tryptophan is solubilized it's absorbed very very rapidly in the digestive system instead of it taking hours to absorb it absorbs in minutes and if you

00:35:55 > warm it up so it's actually tea that you're drinking it absorbs even faster and the it facilitates the blood-brain barrier transport of trip too thin because the collagen protein doesn't have tyrosine and phenylalanine and histidine it those amino acids that would otherwise compete against tryptophan are not present and therefore the the gatekeeper for tryptophan transport is wide open so couldn't I just take out tryptophan capsule and drink some collagen and water and get the effect or do I need to mix them ahead of time well it wouldn't be solubilized it would have to dissolve in your in your gut in your stomach what did soluble eyes they're in a reasonable amount of time or is probably not not real okay if you just take tryptophan and predigested collagen protein you put them together in the same glass of water and stir it it takes about 30 minutes for the tryptophan to dissolve okay so there's a lead time for that now if you wanted to use it for anxiety purposes you could just put the tryptophan and protein into a used water bottle and put

00:36:58 > it in your purse so in your in your bag and take it with you on the road and by the time you got to lunch it would be all dissolved because you'd have these money you know this little bit of stirring effect it would happen so it's not like you need to stir it all the time but the the the peptides in the protein have to stack on the tryptophan to make it soluble and so that takes a while for that to happen this is remarkable I did not know about this this way I was like I miss going to those meetings that this that's vhi meetings I don't get to them as regularly as I did when I lived in the Bay Area because you know you always know stuff like this Steve well that's that's part of just experimenting with things just trying things out you know yeah the the tryptophan here and you've got the protein there and at some point randomly try it and oh wow look at that it that is so phenomenal I've never looked at tryptophan solubility I've looked at 5-hydroxytryptophan Yin 5htp is a very well known sleep remedy and it's one that I it benefits some people long-term

00:37:59 > use maybe is tied with cancer and there are some concerns about it raising serotonin levels in the blood verses the brain what's your take on 5-htp versus tryptophan for sleep or for anxiety it's basically their equivalent in in low doses you know for raising serotonin levels in the in a kind of physiological kind of context but tryptophan is rate limiting is rate limited and therefore you can't really take too much tryptophan easily you really have to work at it whereas 5htp you can you can overdrive the system because 5htp has passed the rate limiting step so it's like you know full blast but in terms of solubility there they're very similar in terms of you know 5-hydroxytryptophan not being as soluble as many compounds are and that the the collagen protein helps dissolve the 5-htp but the 5-htp is fundamentally more soluble than tryptophan so you don't need it as much

00:39:00 > but in terms of the the blood-brain barrier transport system 5-htp is like tryptophan it's at the end of the line it's at the back of the bus and so it's the last one to get on and get through into the brain so that that matters and also there's there's a an enzyme that destroys tryptophan and 5-hydroxytryptophan that's activated by inflammation and so if you happen to be somebody who's in a state of chronic inflammation neither trip to theatre 5-hydroxytryptophan will work very well for you and the collagen protein gives you a technique for sneaking it past that enzyme that would otherwise trash it okay interesting so maybe 5-htp is preferable for some people yeah or for the the collagen 5-htp mixture would be preference so if you okay collagen with a 5-htp not collagen trip defense you you can make you can do either one okay I'm going to try that I do 5e Sophie sometimes if somebody has this inflammatory issue what they'll tend to

00:40:02 > notice is that they'll take tryptophan or 5-hydroxytryptophan before bed to sleep better and even though they may sleep better they don't wake up very well and the next day they feel off I call it a kind of melees where you know just things aren't quite right and you feel off and your brain feels a little bit you know poisoned and that's because that enzyme indole amine dioxygen aids I do burns up the tryptophan and 5-hydroxytryptophan and those byproducts are toxic to the brain so if you take that you take the tryptophan and 5-hydroxytryptophan let's say you know two days later week later and you mix it with the protein the collagen protein and you take it and you don't wake up with that next day melees that means you have high IDO and inflammation and that collagen is sneaking it through your system Wow so for inflamed people mixing 5-htp or tryptophan with collagen before bed is a better move so as a diagnostic technique so you can actually diagnose

00:41:06 > inflammation based on a differential response with the collagen protein so cool so if you're inflamed College is gonna make you feel better the next day if you're not inflamed you'll just you won't get a hangover from it all right this is really cool so this is hacking if you're listening to this and you are curious about your inflammation levels and I actually recommend you get your labs done to your wellness FX panel get your C reactive protein and LP PLA to and I say almost cysteine and c-reactive protein whatever all the different various implements that we talked about all the time but on top of that what Steve's talking about here no lab tests required and you're probably already taking collagen if you listen to the podcast regularly because it's good for you and it's good for your connective tissues and everything else it's a less inflammatory source of protein so you're already doing that here's a test alright there's three things I recommend people do before bed Steve and I want you to tell me why I'm wrong some people really respond well to raw honey before bed okay and these people the the theory goes that when you use raw honey

00:42:10 > it raises and stabilizes your blood your blood glucose levels so not super high but it keeps them stable for six or sometimes more hours so you're not getting hypoglycemic crash so your brain works better because it's properly fueled at night I often tell those people later at it throw some brain octane in there so you have some ketones present as well some people just do fine on plane brain octane some people want honey and brain octane different brains like glucose different brands like the brain octane oil and then there's another group of people who benefits from having collagen before bed and some of them do collagen with brain octane so the idea is some people want the amino acids and the energy from the fat some people want the energy from the fat and glucose and some people want just glucose it seems very individualized I haven't found one thing that works for everyone what are the pros and cons of each of those well they all make sense to me I mean there's raw honey has not only that blood sugar stabilizing effect but has two other effects one is its

00:43:11 > antimicrobial yeah and therefore if you have a sugar fungus interaction Candida for example where when you eat sugar you're going to get fungal mycotoxins it will be produced in your gut the honey will tend to inhibit that especially the brain octane caprylic rest it has a pretty effect but also the the honey anytime you raise your blood sugar above its normal level you're going to get enhanced tryptophan into the brain to produce serotonin and this has to do with the fact that the sugar stimulates the liver to store trip excuse me tyrosine and phenylalanine and histidine those large neutral amino acids when the blood sure goes up they tend to be stored and therefore it alters the ratio of amino acids to facilitate tryptophan moves up in concentration and then it flows into the brain better so you would put the honey into the collagen tryptophan mixture to rock the way it

00:44:13 > works well you could and but I my concern is that any sugar mediated way of augmenting tryptophan has a my product of producing insulin resistance which is a big downside yeah we don't really want insulin we don't really want that yeah in terms of ketones yeah the brain gets used to ketones some people can get revved up on them it might keep them from sleeping or have them sleep with violent and dynamic dreams so you know that would be my concern that somebody would would probably need to be in some level in ketosis a lot of the time to handle that gracefully and collagen is a - it's missing tryptophan so it's not only missing tyrosine and phenylalanine and histidine it's also missing tryptophan so but if you so if you took the collars you mix a little bit of tryptophan in it to replace that one that's missing then I would guess that you would get phenomenal sleep effects from it on a as a as a pre sleep aid okay

00:45:16 > that makes great sense in terms of using the brain octane oil before sleep for ketones any downside to that that you know about oh yeah you rub yourself up too much so some people much energy some people can't sleep because they're so excited okay I get that I know it's just like you know you're sticking your finger in electric socket you're not going to sleep if if it's that stimulating for like for me and for a lot of people having better mitochondrial energy equals better sleep because yeah there's something you know about this but for our listeners this is the glymphatic system like we just sort of figured out that the cells in your brain they kind of drain their fluids at night and it gets pumped out through cerebrospinal fluid and then they reinflates is one of the talks and removing things and it's it uses mitochondria to do that so I have found that my ability to get less sleep and feel amazing in the morning is tied to mitochondrial activity the stronger my mitochondria the better I feel then the less sleep I need in order to feel restored the next day so I can go to

00:46:18 > sleep in three minutes it doesn't matter what's happening because I have controlled my sleep cycles so there you go okay there's also a kind of phenomena that's been noted in some of the chat rooms of people who are taking thyroid hormone where they're now taking a fraction of the retired hormone before bed at night on empty stomach and having better I mean that's obviously mitochondrial thing it's obvious to you and me I may have to try that I'm down to almost no thyroid I used to take quite a bit and I'm down a 2.5 whatever micrograms of t3 and his sustained release in a very low dose and I'm not even taking t4 but I used to take you know ten instead of 2.5 and I took a hundred of t4 so I'm yeah I'm almost done with my thyroid meds but doing it before bed I think's reminding me that and a lot of the people listening to this are on thyroid medication and a lot of them aren't but should be so if you're listening to this and you have brain fog and you're tired and slow and things aren't working right you're cold when

00:47:19 > your friends aren't cold like it's time to start biohacking your thyroid function for sure all right let's see here what other things do we have time to talk about we have about how about t3 in the morning to wake up to I certainly j ce3 mom and what instead of coffee t3 for those people who can't tolerate the MCT or the butter or the coffee they could take a small dose of t3 in the morning is a coffee substitute I take my I actually washed my t3 down with the coffee and eat outside of that well it just you know if you're not climbing the walls if your wife doesn't divorce you it's okay and of course you need the brain octane for more energy like I've got uses for this energy man all right let's see we we don't have time to go into vitamin C or GHB which are the other two things that I would love to pick your brain sometime so well I'd love to have you back on Steve and

00:48:21 > maybe next time I'm in the Bay Area we can actually set up a camera do this live in person which would be the most fun so well we'll set it up but you're always welcome if you have something you want to share just drop me a line you're welcome on the show like you're one of the guys and I mean honestly there's a lot of doctors you know little like they know this thing or they know this thing but honestly if I'm stuck the first guy that I can think of to call as you like honestly it's it's going to be obscure and you're going to know it and I don't know anyone else with that level of just broad-ranging so a lot of respect and and gratitude so thank you thank blast yeah thanks for being on the show and thanks for the work you've done for way longer than I've been doing any of this stuff tell people your URL and where they can find out more about you and you also do individualized coaching sessions for people right I do and you can get in touch with me at project will being calm and go to the Steve page now all my contact information is there you know links to other sites and you know books and stuff there's a free book on antiviral therapy that you can

00:49:22 > download so you know one pager and thyroid hormone it's all there on that one page so that's the best place to go so the the interesting thing people should know about you Steve is that you know aside from being like a national treasure of biohacking is that you're very accessible like if you go to the the third Thursday of the month at 7 p.m. at the Cubberley community center in Palo Alto just go to SVA chai as in Silicon Valley Health Institute dot-com and how to work I think I think we have both calmed our yeah but you can go there and you can learn how to get in there it's five bucks to get in there'll be a lecture from someone who knows a lot about something interesting around biohacking and Steve will be there along with a few other guys who are of similar sets of knowledge and there's a community forum where half hour you can just ask questions and Steve will explain anything and I've learned so much a lot of my biohacking has come from this community of experts they're all there and steve is one of them and it's one of the things I miss most about the Bay Area I know that I'm living up here in Canada a you know in the

00:50:25 > wilderness all right in the wilderness exactly now Steve there's there's a question you're not getting away without answering this and it's on that every guest except one when I forgot has answered and the question is what are your top three recommendations for people who want to perform better people just want to kick more ass this doesn't have to be supplements or drugs just given your life experience the three most important pieces of advice you have for someone it's so contextual I mean there's certain Sleeper things for example that I run into and I deal with clients like for example if you're male and you're 40 years of age or older get your ferret an iron assessment after ferritin and your KBC and your transparent and and free iron measured you know look at that whole issue of iron toxicity should you just have innate blood as a general rule and well I that's how I handle it is like it lets three times a year like clockwork but you know a lot of people don't and they're too busy or they don't like getting stuck with needles you know whatever the reason and this is one of

00:51:28 > those you know one of those things that can sneak up and kill you in two weeks and when you're not expecting it you know you go from being healthy to being sick as a dog in two weeks so um so that would be something that I would put on my list of things that I've talked about it's in my medical directive you know to do in terms of how to respond to issues of anemia and iron supplementation the other thing would be in terms of supplementation of take an ordinary high potency multivitamin and mineral you know this is a lifestyle thing is kind of minimum insurance across the entire spectrum of nutritional needs and the other thing would be about you know the the psychological side the spiritual side of living to old age is cultivate happiness cultivate joy cultivate appreciation in your life that is

00:52:29 > definitely one we've heard before and speaking of living to an old age and for people who are watching us on YouTube YouTube YouTube or iTunes that's like when you combine the two together that doesn't happen for ten more years but where people are watching the video here like you're looking pretty healthy no one would guess you 107 almost twice off but you are one of the the pioneers in anti-aging field and you've applied these things to yourself and it shows in your cognitive swiftness and just the way the way you handle yourself mentally is very impressive so this is a guy who has walked the walk a lot longer than I have and has had I would say phenomenal results so thanks for all the work you do and thanks for being on the show and like what our welcome back and time thank you like chocolate coffee and chocolate have this to our acidifying effect and an eight-hour alkalinizing affect afterwards see I didn't know that about coffee there's not a lot about coffee hacking I haven't read but I would love to see like any

data on that because that would be an amazing post could eat what we're what we are made to eat have a nutrient-dense low inflammation diet low toxin sustainable I mean it all made sense I'm like it's there was this intuition that it couldn't be wrong